In mammals, there are two paralogues of yeast Vps26, VPS26A and VPS26B. VPS26 is a component of the retromer complex composed of VPS26 (VPS26A or VPS26B), VPS29, VPS35, SNX1 and SNX2. VPS26A and VPS26B subunits define distinct retromer complexes. The retromer complex is important in recycling transmembrane receptors from endosomes to the trans-Golgi network (TGN).
Vacuolar protein sorting-associated protein 26B; Vesicle protein sorting 26B; VPS26 retromer complex component B