AF9 Antibodies

Antibodies that detect AF9 can be used in several scientific applications, including Western Blot, Immunohistochemistry, ELISA, Immunocytochemistry and ChIP. These antibodies target AF9 in Human, Mouse and Rat samples. Our AF9 polyclonal, recombinant monoclonal and monoclonal... Antibodies that detect AF9 can be used in several scientific applications, including Western Blot, Immunohistochemistry, ELISA, Immunocytochemistry and ChIP. These antibodies target AF9 in Human, Mouse and Rat samples. Our AF9 polyclonal, recombinant monoclonal and monoclonal antibodies are developed in Rabbit and Mouse. These... Antibodies that detect AF9 can be used in several scientific applications, including Western Blot, Immunohistochemistry, ELISA, Immunocytochemistry and ChIP. These antibodies target AF9 in Human, Mouse and Rat samples. Our AF9 polyclonal, recombinant monoclonal and monoclonal antibodies are developed in Rabbit and Mouse. These antibodies have been verified by Knockdown to confirm specificity to AF9. Find the AF9 antibody that fits your needs. Choose from 1 of 12 AF9 antibodies, which have been validated in experiments with 2 publications and 23 images featured in our data gallery.

Browse primary antibodies for WB, Flow, IHC, ICC/IF, ELISA, IP, and other applications. Antibodies with Advanced Verification data have been validated for... Antibodies that detect AF9 can be used in several scientific applications, including Western Blot, Immunohistochemistry, ELISA, Immunocytochemistry and ChIP. These antibodies target AF9 in Human, Mouse and Rat samples. Our AF9 polyclonal, recombinant monoclonal and monoclonal antibodies are developed in Rabbit and Mouse. These antibodies have been verified by Knockdown to confirm specificity to AF9. Find the AF9 antibody that fits your needs. Choose from 1 of 12 AF9 antibodies, which have been validated in experiments with 2 publications and 23 images featured in our data gallery.

Browse primary antibodies for WB, Flow, IHC, ICC/IF, ELISA, IP, and other applications. Antibodies with Advanced Verification data have been validated for specificity to ensure that the antibody binds to the antigen stated. If you cannot find the antibody you’re looking for, contact us today to develop custom antibodies for specific targets, species and applications.

Target Information

The human AF9 gene is one of the most common fusion partner genes with the ALL1 gene at 11q23 (also called MLL), resulting in the t(9;11)(p22;q23). The AF9 gene is more than 100 kb, and 2 patient breakpoint cluster regions (BCRs) have been identified; BCR1 is within intron 4, previously called site A, whereas BCR2 or site B spans introns 7 and 8. Several different structural elements have been identified in AF9, including a colocalizing in vivo DNA topo II cleavage site and an in vitro DNase I hypersensitive (DNase 1 HS) site in intron 7 in BCR2. Reversibility experiments demonstrated a religation of the topo II cleavage sites. In addition, 2 scaffold associated regions (SARs) are located centromeric to the topo II and DNase I HS cleavage sites and border breakpoint regions in 2 leukemic cells lines: SAR1 is located in intron 4, whereas SAR2 encompasses parts of exons 5-7. The patient breakpoint regions of AF9 share the same structural elements as the MLL BCR. A DNA breakage and repair model for nonhomologous recombination between MLL and its partner genes, particularly AF9, has been proposed.

Synonyms

2210011H10Rik; 2610012I03Rik; 3830408D16Rik; Af9; Af-9; AF-9 protein; ALL1-fused gene from chromosome 9 protein; D4Ertd321e; MLLT3; MLLT3, super elongation complex subunit; myeloid/lymphoid or mixed lineage-leukemia translocation to 3 homolog; myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog); translocated to, 3; myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 3; myeloid/lymphoid or mixed-lineage leukemia translocated to chromosome 3 protein; Myeloid/lymphoid or mixed-lineage leukemia translocated to chromosome 3 protein homolog; myeloid/lymphoid or mixed-lineage leukemia, translocated to, 3; myeloid/lymphoid or mixed-lineage leukemia,translocated to, 3 (trithorax homolog, Drosophila); myeloid/lymphoid or mixed-lineage leukemia; translocated to 3; myeloid/lymphoid or mixed-lineage leukemia; translocated to, 3; protein AF-9; translocated to, 3; YEATS domain-containing protein 3; YEATS3

AF9 Antibodies

Target Information

Synonyms

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