Anti-CD11b Antibodies

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CD11b Antibodies

Antibodies that detect CD11b can be used in several scientific applications, including Flow Cytometry, Immunohistochemistry, Western Blot, Immunocytochemistry and Immunoprecipitation. These antibodies target CD11b in Human, Mouse, Baboon, Rhesus Monkey and Cynomolgus Monkey samples. Our CD11b monoclonal, polyclonal and recombinant monoclonal antibodies are developed in Mouse, Rat, Rabbit and Goat. These antibodies have been verified by Cell treatment and Relative expression to confirm specificity to CD11b. Find the CD11b antibody that fits your needs. Choose from 1 of 182 CD11b antibodies, which have been validated in experiments with 10125 publications and 1822 images featured in ... View more Antibodies that detect CD11b can be used in several scientific applications, including Flow Cytometry, Immunohistochemistry, Western Blot, Immunocytochemistry and Immunoprecipitation. These antibodies target CD11b in Human, Mouse, Baboon, Rhesus Monkey and Cynomolgus Monkey samples. Our CD11b monoclonal, polyclonal and recombinant monoclonal antibodies are developed in Mouse, Rat, Rabbit and Goat. These antibodies have been verified by Cell treatment and Relative expression to confirm specificity to CD11b. Find the CD11b antibody that fits your needs. Choose from 1 of 182 CD11b antibodies, which have been validated in experiments with 10125 publications and 1822 images featured in our data gallery.

Browse primary antibodies for WB, Flow, IHC, ICC/IF, ELISA, IP, and other applications. Antibodies with Advanced Verification data have been validated for specificity to ensure that the antibody binds to the antigen stated. If you cannot find the antibody you're looking for, contact us today to develop custom antibodies for specific targets, species and applications.

Target Information

CD11b (integrin alpha-M, ITGAM, integrin alpha-X, ITGAX) is a 165 kDa adhesion molecule that associates non-covalently with integrin beta-2 (CD18). The CD11b/CD18 heterodimeric complex is also known as integrin alpha-M beta-2, Mac-1, and CR3 (complement receptor 3). CD11b is expressed on the surface of monocytes/macrophages, granulocytes, activated lymphocytes, a subset of NK cells, a subset of dendritic cells, and microglia in the brain. CD11b/CD18 functions as the receptor for ICAM-1 (CD54), ICAM-2 (CD102), ICAM-4 (CD242), CD14, CD50, CD23, heparin, iC3b, fibrinogen, and Factor X -these adhesions are critical for cell-cell and cell-matrix interactions. CD11b is expressed on 8% of spleen cells, 44% of bone marrow cells, and less than 1% of thymocytes, and is commonly used as a microglial marker in nervous tissue. The expression of CD11b increases during monocyte maturation and expression levels vary on tissue macrophages. Further, peritoneal macrophages are reported to express higher levels of CD11b than splenic macrophages. Diseases associated with CD11b dysfunction include systemic lupus erythematosus 6 and ITGAM-related susceptibility to systemic lupus erythematosus.

Synonyms

antigen CD11b (p170); antigen CD11b (p170); macrophage antigen alpha polypeptide; CD11 antigen-like family member B; CD11b; CD11B (p170); CD11b/CD18; cell surface glycoprotein MAC-1 alpha subunit; cell surface glycoprotein MAC-1 subunit alpha; complement component 3 receptor 3 subunit; complement component receptor 3 alpha-a; complement receptor type 3; CR3; CR-3 alpha chain; CR3A; F730045J24Rik; integrin alpha M; integrin alpha-M; integrin subunit alpha M; integrin, alpha M; integrin, alpha M (complement component 3 receptor 3 subunit); ITGAM; Leukocyte adhesion receptor MO1; leukocyte integrin alpha-M chain; LOC100351865; Ly-40; MAC1; Mac-1; Mac-1 alpha; Mac-1 alpha (Mac1A); MAC-1 alpha subunit; MAC1A; Mac-1a; macrophage antigen alpha; macrophage antigen alpha polypeptide; MGC117044; MO1A; Neutrophil adherence receptor; neutrophil adherence receptor alpha-M subunit; SLEB6; unnamed protein product

Target Video

6320250568112

CD11b antibodies from Thermo Fisher Scientific

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Learn more about CD11b primary antibodies that can be used in Flow Cytometry, Immunohistochemistry, Western Blot and Immunocytochemistry in Human, Mouse, Baboon and Rhesus monkey samples.