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Aminoacyl-tRNA synthetases are a class of enzymes that charge tRNAs with their cognate amino acids. The protein encoded by this gene is a cytoplasmic enzyme which belongs to the class II family of aminoacyl-tRNA synthetases. The enzyme is responsible for the synthesis of histidyl-transfer RNA, which is essential for the incorporation of histidine into proteins. The gene is located in a head-to-head orientation with HARSL on chromosome five, where the homologous genes share a bidirectional promoter. The gene product is a frequent target of autoantibodies in the human autoimmune disease polymyositis/dermatomyositis.
CMT2W; dead end homolog 1; Dnd1; FLJ20491; HARS; HARS1; HARSL; HARSL protein; HisRS; histidine translase; histidine tRNA ligase; histidine--tRNA ligase; histidine--tRNA ligase, cytoplasmic; Histidyl-tRNA synthetase; histidyl-tRNA synthetase 1; histidyl-tRNA synthetase, cytoplasmic; HRS; im:7136719; MMHRS; Unknown (protein for IMAGE:7951312); USH3B; zgc:92215
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