MEKK4 Antibodies

Target Information

This gene encodes a TBP- (TATA box-binding protein) associated phosphoprotein that represses both basal and activated levels of transcription. The encoded protein is phosphorylated in vivo and this phosphorylation affects its interaction with TBP. This protein contains a histone fold motif at the amino terminus, a TBP-binding domain, and a glutamine- and alanine-rich region. The binding of DR1 repressor complexes to TBP-promoter complexes may establish a mechanism in which an altered DNA conformation, together with the formation of higher order complexes, inhibits the assembly of the preinitiation complex and controls the rate of RNA polymerase II transcription.

Synonyms

D17Rp17; D17Rp17e; dJ473J16.1 (mitogen-activated protein kinase kinase kinase 4); JNKK1; KIAA0213; MAP three kinase 1; MAP/ERK kinase kinase 4; MAP2K4; Map3k4; MAPK/ERK kinase kinase 4; MAPKKK4; MEK kinase 4; Mek4b; MEKK 4; MEKK4; mitogen activated protein kinase kinase kinase 4; mitogen-activated protein kinase kinase kinase 4; mKIAA0213; MTK1; predicted protein of HQ0412; PRKMK4; PRO0412; RP17; Rp17a; SAPK/ERK kinase 1; SERK1; SSK2/SSK22 MAP kinase kinase kinase, yeast, homolog of; Tas; T-associated sex reversal