RGA1 Antibodies

Target Information

RGA1 encodes a cytoplasmic Rho-family GTPase-activating protein that concentrates transiently at cortical division-site landmarks (e.g., the bud neck/bud scars) and can redistribute to the cytoplasm under replication stress, consistent with a role in spatial control of polarity signaling. The protein is modular, featuring tandem N-terminal LIM zinc-binding domains (protein-interaction/scaffolding modules) followed by a C-terminal RhoGAP catalytic domain that stimulates GTP hydrolysis on its target GTPase. Functionally, RGA1 negatively regulates the pheromone-response MAPK pathway and polarized morphogenesis by down-modulating the activity of the polarity GTPase Cdc42, thereby contributing to proper bud-site selection and septin organization and preventing inappropriate Cdc42 repolarization after cytokinesis.

Synonyms

F2I9.19; F2I9_19; REPRESSOR OF GA; REPRESSOR OF GA1-3 1; RGA