Antibodies that detect SALL1 can be used in several scientific applications, including Flow Cytometry, Immunocytochemistry, Western Blot, Immunohistochemistry (Frozen) and Immunohistochemistry. These antibodies target SALL1 in Mouse, Human and Rat samples. Our SALL1 monoclonal and polyclonal antibodies are developed in Rat and Rabbit. These antibodies have been verified by Relative expression to confirm specificity to SALL1. Find the SALL1 antibody that fits your needs. Choose from 1 of 6 SALL1 antibodies, which have been validated in experiments with 15 images featured in our data gallery.
Browse primary antibodies for WB, Flow, IHC, ICC/IF, ELISA, IP, and other applications. Antibodies with Advanced Verification data have been validated for specificity to ensure that the antibody binds to the antigen stated. If you cannot find the antibody you re looking for, contact us today to develop custom antibodies for specific targets, species and applications. View more
Sall1, which encodes a zinc finger protein, functions as a transcriptional repressor and interacts physically with histone deacetylase and other components of the chromatin remodeling NuRD complex. It is unknown whether the transcriptional repression is solely dependent on histone deacetylase activity. Gene expression profiling has identified Sall1 as a microglial signature gene. Microglia are the resident macrophages of the central nervous system (CNS). Sall1 is also expressed in abundance in the mesenchyme-derived structure from condensed mesenchyme, S-comma-shaped bodies, to renal tubules and podocytes. Sall1 has been identified as a key transcription factor in self-renewal renal progenitor cells. Sall1 is required to maintain the stemness of nephron progenitor cells by restraining their differentiation into renal vesicles. Defects in SALL1 are the cause of Townes-Brocks syndrome as well as bronchio-oto-renal syndrome. Heterozygous mutations of human SALL1 leading to Townes Brocks syndrome features dysplastic ears, preaxial polydactyly, imperforate anus, and less commonly, kidney and heart anomalies (Kohlhase et al. 1998). Two transcript variants encoding different isoforms have been found for this gene.
sal-3; sal-like protein 1; zinc finger protein Spalt-3
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