UVR8 Antibodies

Target Information

UVR8 encodes a plant UV-B photoreceptor that is present in both the cytosol and nucleus, with UV-B exposure promoting rapid nuclear accumulation where it can associate with chromatin and regulate UV-B-responsive transcriptional programs. Structurally, UVR8 is an RCC1-like protein dominated by a seven-bladed beta-propeller core that forms a stable homodimer in the absence of UV-B; UV-B perception is intrinsic to the protein (no external chromophore) and is mediated by key tryptophan residues at the dimer interface whose excitation destabilizes a network of cross-dimer salt bridges, driving reversible dimer-to-monomer conversion that initiates signaling. Functionally, monomeric UVR8 engages the E3 ubiquitin ligase COP1 through a critical C-terminal segment to promote expression of UV-protective genes (including regulators such as HY5), supporting acclimation responses such as induction of phenylpropanoid/flavonoid biosynthesis and broader photomorphogenic and stress-tolerance outputs under UV-B irradiation.

Synonyms

AT5G63860; MGI19.7; MGI19_7; UVB-RESISTANCE 8