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CD268 (BAFF Receptor) Monoclonal Antibody (eBio7H22-E16), FITC, eBioscience™
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-Flow-20170216130641.jpg?time=20240507 "CD268 (BAFF Receptor) Antibody in Flow Cytometry (Flow)")
FIGURE: 1 / 4
CD268 (BAFF Receptor) Antibody (11-5943-82) in Flow
Staining of BALB/c splenocytes with Anti-Mouse CD19 PE (Product # 12-0193-82) and 0.125 µg of FITC Rat IgG1 kappa Isotype Control (Product # 11-4301-82) (left) or 0.125 µg of Anti-Mouse CD268 (BAFF Receptor) FITC (right). Cells in the lymphocyte gate were used for analysis.
-Flow-20170216130641.jpg?time=20240507)
-Flow-20170216130641.jpg?time=20240507?time=20240507 "CD268 (BAFF Receptor) Antibody (11-5943-82) in Flow")
Product Details
11-5943-82
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Mouse
Published species
Mouse
Host/Isotype
Rat
/ IgG1, kappa
Recommended Isotype Control
Class
Monoclonal
Type
Antibody
Clone
eBio7H22-E16
Conjugate
Excitation/Emission Max
498/517 nm
View spectra
Form
Liquid
Concentration
0.5 mg/mL
Amount
100 µg
Purification
Affinity chromatography
Storage buffer
PBS, pH 7.2
Contains
0.09% sodium azide
Storage conditions
4°C, store in dark, DO NOT FREEZE!
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Description: The monoclonal antibody eBio7H22.E16 reacts with mouse BAFF-Receptor, a type III transmembrane TNF receptor family member. BAFF-R was found to be the predominant BAFF receptor expressed on peripheral B cells, in both humans and mice. The receptor is found on the surface of all B220+ B cells found in spleen. BAFF-R is expressed on activated/memory subsets of T-cells and is important for splenic B cell maturation and survival and is a major mediator of BAFF- dependent costimulatory responses in peripheral B and T cells. BAFF-R can cause a high level of autoimmune disease and a defect in BAFF-R will cause a decrease in generating mature B-Cells The ligand for the BAFF-R is BAFF also known as BLyS.
Applications Reported: This eBio7H22-E16 antibody has been reported for use in flow cytometric analysis.
Applications Tested: This eBio7H22-E16 antibody has been tested by flow cytometric analysis of mouse splenocytes. This can be used at less than or equal to 0.25 µg per test. A test is defined as the amount (µg) of antibody that will stain a cell sample in a final volume of 100 µL. Cell number should be determined empirically but can range from 10^5 to 10^8 cells/test. It is recommended that the antibody be carefully titrated for optimal performance in the assay of interest.
Excitation: 488 nm; Emission: 520 nm; Laser: Blue Laser.
Filtration: 0.2 µm post-manufacturing filtered.
Target Information
Tumor necrosis factor receptor superfamily member 13C (TNFRSF13C), also known as BAFFR, is a protein in humans is encoded by the TNFRSF13C gene. The BAFFR gene is mapped to chromosome 22q13. 1-q13. 31. It has got 184 amino acid transmembrane protein which is 56% identical to the mouse protein. B cell-activating factor (BAFF) enhances B-cell survival in vitro and is a regulator of the peripheral B-cell population. BAFF plays a crucial role in B cell development and can function through receptors other than BCMA.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: b cell-activating factor receptor; B-cell maturation defect; B-cell maturation defect 1; B-cell-activating factor receptor; BAFF receptor; BAFF-R; BLyS receptor 3; CD268; Tumor necrosis factor receptor superfamily member 13C
Gene Aliases: 2010006P15Rik; BAFF-R; Baffr; Bcmd; Bcmd-1; Bcmd1; Br3; Lvis22; Tnfrsf13c
UniProt ID: (Mouse) Q9D8D0
Entrez Gene ID: (Mouse) 72049
B cell homeostasis
immune system process
positive regulation of germinal center formation
positive regulation of B cell proliferation
T cell costimulation
B cell costimulation
positive regulation of T cell proliferation
positive regulation of interferon-gamma biosynthetic process
regulation of immune response
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If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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