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Proteintech
Cathepsin B Polyclonal Antibody
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Product Details
12216-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse
Published species
Human,
Mouse,
Rat,
Xenopus
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Cathepsin B Fusion Protein Ag2898 (1-339 aa encoded by BC010240)
Conjugate
Form
Liquid
Concentration
0.33 mg/mL
Amount
49.5 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
Immunogen sequence: MWQLWASLC CLLVLANARS RPSFHPVSDE LVNYVNKRNT TWQAGHNFYN VDMGYLKRLC GTFLGGPKPP QRVMFTEDLK LPASFDAREQ WPQCPTIKEI RDQGSCGSCW AFGAVEAISD RICIHTNAHV SVEVSAEDLL TCCGSMCGDG CNGGYPAEAW NFWTRKGLVS GGLYESHVGC RPYSIPPCEH HVNGSRPPCT GEGDTPKCSK ICEPGYSPTY KQDKHYGYNS YSVSNSEKDI MAEIYKNGPV EGAFSVYSDF LLYKSGVYQH VTGEMMGGHA IRILGWGVEN GTPYWLVANS WNTDWGDNGF FKILRGQDHC GIESEVVAGI PRTDQYWEKI (1-339 aa encoded by BC010240)
Target Information
Cathepsin B is a gene located on chromosome 8p23.1 that encodes a lysosomal cysteine protease involved in intracellular protein degradation. As a member of the cathepsin family, Cathepsin B plays a crucial role in the lysosomal pathway, facilitating the breakdown of proteins into amino acids, which can then be recycled for cellular functions. In addition to its proteolytic activity within lysosomes, Cathepsin B is also implicated in extracellular matrix remodeling, cellular invasion, and apoptotic pathways. Its expression and activity are often upregulated in various cancer types, including breast, colon, and pancreatic cancers, where it contributes to tumor progression and metastasis by degrading extracellular matrix components and promoting tumor cell invasion. Due to these roles, Cathepsin B is considered a potential biomarker for cancer prognosis and a target for therapeutic intervention aimed at inhibiting cancer cell dissemination. Research continues to explore its broader implications in diseases related to protease activity and inflammation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: amyloid precursor protein secretase; APP secretase; APPS; Cathepsin B; Cathepsin B1; cysteine protease; epididymis secretory sperm binding protein; keratolytic winter erythema (Oudtshoorn skin disease); lysosomal proteinase cathepsin B; preprocathepsin B; unnamed protein product
Gene Aliases: APPS; CB; CPSB; CTSB; KWE; RECEUP
UniProt ID: (Human) P07858, (Mouse) P10605
Entrez Gene ID: (Human) 1508, (Mouse) 13030
proteolysis
thyroid hormone generation
collagen catabolic process
epithelial cell differentiation
regulation of apoptotic process
decidualization
viral entry into host cell
proteolysis involved in cellular protein catabolic process
cellular response to thyroid hormone stimulus
regulation of catalytic activity
negative regulation of cell death
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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