This Antibody was verified by Knockdown to ensure that the antibody binds to the antigen stated. View Details
This antibody is predicted to react with bovine, canine, chicken, human, mouse, non-human primate, Xenopus and zebrafish based on 100% sequence homology.
This antibody is specific for the ~29 kDa 14-3-3 protein. Immunolabeling is blocked by preadsorption of the antibody with the protein used to generate the antibody.
14-3-3, a family of acidic and soluble proteins, highly conserved in amino acid sequences from yeast to mammals, is expressed in all eukaryotic cells. Seven isoforms(beta, gamma, epsilon, eta, zeta, sigma and tau/theta) encoded by seven distinct genes are identified in mammals and forms homo- and hetero- dimeric cup-shaped structures. As 14-3-3 is interacted with more than 100 binding partners, it regulates key proteins involved in various biological processes such as signal trans-duction, cell cycle, transcriptional control, cell proliferation, apoptosis, and ion channel physiology. Most 14-3-3 requires phosphorylation of serine or threonine residues in the target sequence. This protein is abundantly expressed in the brain and has been detected in the cerebrospinal fluid of patients with different neurological disorders.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: 14-3-3 protein beta-subtype; 14-3-3 protein beta/alpha; 14-3-3 protein beta/alpha, N-terminally processed; 3-monooxygenase/tryptophan 5 monooxygenase activation protein beta polypeptide; KCIP 1; KCIP-1; KCIP1; Prepronerve growth factor RNH-1; Protein kinase C inhibitor protein 1; RP1-148E22.1; tryosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein beta polypeptide; tryosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein gamma; tyrosine 3-monooxgenase/tryptophan 5 monooxgenase activation protein beta polypeptide; tyrosine 3-monooxgenase/tryptophan 5 monooxgenase activation protein, beta polypeptide; tyrosine 3-monooxgenase/tryptophan 5-monooxgenase activation protein, beta polypeptide; tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide; tyrosine 3/tryptophan 5 -monooxygenase activation protein beta polypeptide; tyrosine 3/tryptophan 5 -monooxygenase activation protein, beta polypeptide
Gene Aliases: Ywhab
UniProt ID: (Rat) P35213
Entrez Gene ID: (Rat) 56011
Molecular Function: chaperone