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Invitrogen
CD365 (Tim-1) Recombinant Rabbit Monoclonal Antibody (P365D), eBioscience™
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FIGURE: 1 / 4
CD365 (Tim-1) Antibody (14-3658-82) in Flow
769P renal cell adenocarcinoma cells were stained with 0.25 µg of Recombinant Rabbit IgG Monoclonal Isotype Control (Product # 14-4616-82) (purple histogram) or 0.25 µg of CD365 Recombinant Rabbit Monoclonal Antibody, purified (pink histogram), followed by Goat anti-Rabbit IgG (H+L) Cross-Adsorbed Secondary Antibody, APC (Product # A-10931). Viable cells were used for analysis, as determined by Fixable Viability Dye eFluor 450 (Product # 65-0863-18).
Product Details
14-3658-82
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Expression System
Expi293
Class
Recombinant Monoclonal
Type
Antibody
Clone
P365D
Immunogen
Protein corresponding to Human CD365 (aa22-aa129)
Conjugate
Form
Liquid
Concentration
0.5 mg/mL
Amount
100 µg
Purification
Protein A
Storage buffer
PBS, pH 7.4
Contains
0.09% sodium azide
Storage conditions
4°C
Shipping conditions
Wet ice
RRID
Product Specific Information
Description: This P365D recombinant rabbit monoclonal antibody reacts with human CD365, which is also known as Tim-1, Kim-1, or Havcr1.
Applications Tested: This P365D antibody has been tested by flow cytometric analysis of 769P cells. This may be used at less than or equal to 0.5 µg per test. A test is defined as the amount (µg) of antibody that will stain a cell sample in a final volume of 100 µL. Cell number should be determined empirically but can range from 10^5 to 10^8 cells/test. It is recommended that the antibody be carefully titrated for optimal performance in the assay of interest.
Filtration: 0.2 µm post-manufacturing filtered.
Target Information
CD365 also known as T-cell immunoglobulin and mucin domain 1 (Tim-1) is a type 1 surface glycoprotein that consists of extracellular N-terminal immunoglobulin V-like domain and a mucin domain, and a short cytoplasmic tail. The endogenous ligand for CD365 is Tim-4. In addition, CD365 is known to be a cellular receptor or co-receptor for a number of viruses including hepatitis A and C viruses, Ebola virus, Marburg virus, Dengue virus, Zika virus, West Nile virus, and Japanese encephalitis virus. The direct binding of the viruses by CD365 occurs via phosphatildyl-serine exposed on viral envelopes. Polymorphisms within human CD365 gene (HAVCR1) are associated with susceptibility to infection and the disease severity. CD365 has also been implicated in the T cell co-stimulation. CD365 is primarily expressed in epithelial cells. It is also highly expressed in A549, 769-P and Caco-2 and cell lines. CD365 exists also as a soluble protein generated by metalloproteinase mediated proteolytic cleavage of the surface protein.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: CD365; HAVcr-1; HAVCR1; Hepatitis A virus cellular receptor 1; Kidney injury molecule 1; KIM-1; T cell immunoglobin domain and mucin domain protein 1; T-cell immunoglobulin and mucin domain-containing protein 1; T-cell immunoglobulin mucin family member 1; T-cell immunoglobulin mucin receptor 1; T-cell membrane protein 1; TIM; TIMD-1; unnamed protein product
Gene Aliases: CD365; HAVCR; HAVCR-1; HAVCR1; KIM-1; KIM1; TIM; TIM-1; TIM1; TIMD-1; TIMD1
UniProt ID: (Human) Q96D42
Entrez Gene ID: (Human) 26762
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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