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Proteintech
PPP6C Polyclonal Antibody
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Product Details
15852-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Published species
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
PPP6C Fusion Protein Ag8670 (1-305 aa encoded by BC006990)
Conjugate
Form
Liquid
Concentration
0.13 mg/mL
Amount
19.5 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
Immunogen sequence: MAPLDLDKY VEIARLCKYL PENDLKRLCD YVCDLLLEES NVQPVSTPVT VCGDIHGQFY DLCELFRTGG QVPDTNYIFM GDFVDRGYYS LETFTYLLAL KAKWPDRITL LRGNHESRQI TQVYGFYDEC QTKYGNANAW RYCTKVFDML TVAALIDEQI LCVHGGLSPD IKTLDQIRTI ERNQEIPHKG AFCDLVWSDP EDVDTWAISP RGAGWLFGAK VTNEFVHINN LKLICRAHQL VHEGYKFMFD EKLVTVWSAP NYCYRCGNIA SIMVFKDVNT REPKLFRAVP DSERVIPPRT TTPYFL (1-305 aa encoded by B C006990)
Target Information
Distinct DNA repair pathways minimize the consequences of mutagenic events. Reactive oxygen species (ROS) are highly reactive atoms with an unpaired electron that are conducive to double-strand DNA breaking events. Artemis, named after the Greek goddess for the protection of children, is one of the major proteins contributing to the preservation of double-strand breaks in DNA by cutting away the damaged parts of the DNA, which allows the strands to rejoin. Artemis is a single-strand-specific 5' to 3' exonuclease that forms a complex with the 469 kDa DNA-dependent protein kinase (DNA-PKcs). DNA-PKcs phosphorylates Artemis, and Artemis acquires endonucleolytic activity on 5' and 3' overhangs and hairpins. These activities are essential for V(D)J recombination and for the 5' and 3' overhang processing in nonhomologous DNA end joining.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: ANKRD33; FLJ34236; PP-V; PP6C; Protein phosphatase V; serine/threonine protein phosphatase catalytic subunit; Serine/threonine-protein phosphatase 6 catalytic subunit; unnamed protein product; UNQ5837
Gene Aliases: 2310003C10Rik; PP6; PP6C; PPP6; PPP6C; Ppv
UniProt ID: (Human) O00743, (Rat) Q64620, (Mouse) Q9CQR6
Entrez Gene ID: (Human) 5537, (Rat) 171121, (Mouse) 67857
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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