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Proteintech
PAN2 Polyclonal Antibody
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Product Details
16427-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Published species
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
PAN2 Fusion Protein Ag9670 (850-1198 aa encoded by BC024043)
Conjugate
Form
Liquid
Concentration
0.14 mg/mL
Amount
21 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
Immunogen sequence: ATVVHILDS RTGGSLVAHI KVGETYHQRK EGVTHQQWYL FNDFLIEPID KHEAVQFDMN WKVPAILYYV KRNLNSRYNL NIKNPIEASV LLAEASLARK QRKTHTTFIP LMLNEMPQIG DLVGLDAEFV TLNEEEAELR SDGTKSTIKP SQMSVARITC VRGQGPNEGI PFIDDYISTQ EQVVDYLTQY SGIKPGDLDA KISSKHLTTL KSTYLKLRFL IDIGVKFVGH GLQKDFRVIN LMVPKDQVLD TVYLFHMPRK RMISLRFLAW YFLDLKIQGE THDSIEDART ALQLYRKYLE LSKNGTEPES FHKVLKGLYE KGRKMDWKVP EPEGQTSPKN AAVFSSVLAL (850-1198 aa encoded by BC024043)
Target Information
This gene encodes a coregulator for the alpha and beta estrogen receptors and the orphan nuclear receptor NR1D2. The protein localizes to the nucleus, and is thought to have both coactivator and corepressor functions. Its interaction with nuclear receptors is independent of the AF2 domain on the receptors, which is known to regulate interaction with other coreceptors. Two alternatively spliced transcript variants for this gene have been described. However, the full length nature of one of the variants has not been determined.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: AN2 polyA specific ribonuclease subunit homolog; Inactive ubiquitin carboxyl-terminal hydrolase 52; inactive ubiquitin carboxyl-terminal hydrolase 52 {ECO:0000255|HAMAP-Rule:MF_03182}; PAB-dependent poly(A)-specific ribonuclease subunit 2; PAB-dependent poly(A)-specific ribonuclease subunit PAN2; PAB-dependent poly(A)-specific ribonuclease subunit PAN2 {ECO:0000255|HAMAP-Rule:MF_03182}; PAB1P-dependent poly(A)-nuclease; PAB1P-dependent poly(A)-nuclease {ECO:0000255|HAMAP-Rule:MF_03182}; PAB1P-dependent poly(A)-specific ribonuclease; PABP-dependent poly(A) nuclease 2; PAN deadenylation complex catalytic subunit 2; PAN deadenylation complex catalytic subunit 2 {ECO:0000255|HAMAP-Rule:MF_03182}; PAN deadenylation complex subunit 2; PAN2 poly(A) specific ribonuclease subunit homolog; PAN2 polyA specific ribonuclease subunit homolog; PAN2-PAN3 deadenylation complex catalytic subunit PAN2; Poly(A)-nuclease deadenylation complex subunit 2; ubiquitin specific peptidase 52; ubiquitin specific protease 52; unnamed protein product
Gene Aliases: 1200014O24Rik; AI047843; AW742773; KIAA0710; mKIAA0710; PAN2; USP52
UniProt ID: (Human) Q504Q3, (Mouse) Q8BGF7
Entrez Gene ID: (Human) 9924, (Rat) 408200, (Mouse) 103135
3'-5'-exoribonuclease activity
nucleic acid binding
nuclease activity
exonuclease activity
poly(A)-specific ribonuclease activity
thiol-dependent ubiquitin-specific protease activity
protein binding
hydrolase activity
metal ion binding
exoribonuclease
RNA metabolism protein
nucleic acid metabolism protein
nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay
nuclear-transcribed mRNA poly(A) tail shortening
mRNA processing
positive regulation of cytoplasmic mRNA processing body assembly
RNA phosphodiester bond hydrolysis, exonucleolytic
nuclear-transcribed mRNA catabolic process, exonucleolytic
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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