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Invitrogen
CD94 Monoclonal Antibody (DX22), APC, eBioscience™
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FIGURE: 1 / 1
CD94 Antibody (17-0949-42) in Flow
Normal human peripheral blood cells were stained with CD56 (NCAM) Monoclonal Antibody, eFluor 450 (Product # 48-0566-42) and Mouse IgG1 kappa Isotype Control, APC (Product # 17-4714-82) (left) or CD94 Monoclonal Antibody, APC (right). Cells in the lymphocyte gate were used for analysis.
Product Details
17-0949-42
Product Specifications
Species Reactivity
Human
Host/Isotype
Mouse
/ IgG1, kappa
Recommended Isotype Control
Class
Monoclonal
Type
Antibody
Clone
DX22
Conjugate
Excitation/Emission Max
651/660 nm
View spectra
Form
Liquid
Concentration
5 µL/Test
Purification
Affinity chromatography
Storage buffer
PBS, pH 7.2, with BSA
Contains
0.09% sodium azide
Storage conditions
4°C, store in dark, DO NOT FREEZE!
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Description: The DX22 monoclonal antibody reacts with human CD94, a 70 kDa type II transmembrane glycoprotein. CD94 belongs to the C-type lectin superfamily and is present as a heterodimer with NKG2 on the surface. CD94 is expressed by NK cells, a subset of gd T cells, and NKT cells and plays an important role in adhesion and activation of NK cell lineage.
Applications Reported: This DX22 antibody has been reported for use in flow cytometric analysis.
Applications Tested: This DX22 antibody has been pre-diluted and tested by flow cytometric analysis of normal human peripheral blood cells. This may be used at 5 µL (0.125 µg) per test. A test is defined as the amount (µg) of antibody that will stain a cell sample in a final volume of 100 µL. Cell number should be determined empirically but can range from 10^5 to 10^8 cells/test.
Excitation: 633-647 nm; Emission: 660 nm; Laser: Red Laser
Target Information
Natural killer (NK) cells, like CD94, are a distinct lineage of lymphocytes that mediate cytotoxic activity and secrete cytokines upon immune stimulation. Several genes of the C-type lectin superfamily, including members of the NKG2 family, are expressed by NK cells and may be involved in the regulation of NK cell function. KLRD1 (CD94) is an antigen preferentially expressed on NK cells and is classified as a type II membrane protein because it has an external C terminus. Three transcript variants encoding two different isoforms have been found for this gene.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: CD94; CD94 antigen; Killer cell lectin-like receptor subfamily D member 1; killer cell lectin-like receptor subfamily D, member 1; KLRD1; KP43; natural killer cell receptor; Natural killer cells antigen CD94; NK cell receptor; unnamed protein product
Gene Aliases: CD94; KLRD1
UniProt ID: (Human) Q13241
Entrez Gene ID: (Human) 3824
negative regulation of T cell mediated cytotoxicity
stimulatory C-type lectin receptor signaling pathway
natural killer cell mediated immunity
adaptive immune response
immune system process
cell surface receptor signaling pathway
regulation of natural killer cell activation
innate immune response
negative regulation of natural killer cell mediated cytotoxicity
positive regulation of natural killer cell mediated cytotoxicity
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