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Proteintech
LSR Polyclonal Antibody
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Product Details
18216-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
LSR Fusion Protein Ag12961 (339-589 aa encoded by BC004381)
Conjugate
Form
Liquid
Concentration
0.18 mg/mL
Amount
27 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
Immunogen sequence: SMRVLYYME KELANFDPSR PGPPSGRVER AMSEVTSLHE DDWRSRPSRG PALTPIRDEE WGGHSPRSPR GWDQEPAREQ AGGGWRARRP RARSVDALDD LTPPSTAESG SRSPTSNGGR RSRAYMPPRS RSRDDLYDQD DSRDFPRSRD PHYDDFRSRE RPPADPRSHH HRTRDPRDNG SRSGDLPYDG RLLEEAVRKK GSEERRRPHK EEEEEAYYPP APPPYSETDS QASRERRLKK NLALSRESLV V (339-589 aa encoded by BC004381)
Target Information
Lipolysis-stimulated lipoprotein receptor (LSR), encoded by the LSR gene, is a crucial component in lipid metabolism, particularly involved in the endocytosis of triglyceride-rich lipoproteins. It is typically expressed in liver and adipose tissues, playing a pivotal role in maintaining lipid and glucose homeostasis. LSR binds to lipoproteins in the presence of free fatty acids, facilitating the uptake and clearance of lipids from the bloodstream, which is significant in preventing atherosclerosis and other lipid-related disorders. The protein functions as a multi-subunit complex, which includes two isoforms, LSRα and LSRβ, each contributing to lipoprotein metabolism. Research has highlighted its involvement in metabolic processes and its potential impacts on obesity and insulin resistance. LSR has also been studied in the context of hepatic lipid accumulation, where its downregulation is associated with increased lipid deposition in the liver, suggesting its importance in preventing non-alcoholic fatty liver disease (NAFLD). Due to its central role in lipid metabolism, LSR has emerged as a potential therapeutic target for metabolic diseases and cardiovascular conditions.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: Angulin-1; Angulin-3; immunoglobulin-like domain containing receptor 3; lipolysis stimulated receptor; Lipolysis-stimulated lipoprotein receptor; Lipolysis-stimulated receptor; lipolysis-stimulated remnant; Lipolysis-stimulated remnant receptor; LISCH protein; Liver-specific bHLH-Zip transcription factor; liver-specific bHLH-Zip transcription factor 7; Liver-specific gene on mouse chromosome 7 protein; unnamed protein product
Gene Aliases: ILDR3; LISCH; LISCH7; LSR
UniProt ID: (Human) Q86X29, (Rat) Q9WU74, (Mouse) Q99KG5
Entrez Gene ID: (Human) 51599, (Rat) 64355, (Mouse) 54135
liver development
epithelial structure maintenance
maintenance of blood-brain barrier
establishment of blood-brain barrier
establishment of skin barrier
protein localization to tricellular tight junction
tricellular tight junction assembly
regulation of lipid metabolic process
receptor-mediated endocytosis
lipoprotein transport
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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