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NeoBiotechnologies
EIF4E Monoclonal Antibody (PCRP-EIF4E-1D3)
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Product Details
1977-MSM1-P0
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Mouse
/ IgG2a
Class
Monoclonal
Type
Antibody
Clone
PCRP-EIF4E-1D3
Immunogen
Recombinant full-length human EIF4E protein
Conjugate
Form
Liquid
Concentration
200 µg/mL
Amount
20 µg
Purification
Protein A/G
Storage buffer
PBS, pH 7.4, with 0.05% BSA
Contains
0.05% sodium azide
Storage conditions
4°C
Shipping conditions
Ambient (domestic); Wet ice (international)
Target Information
eIF4E is involved in several cellular processes including enhanced translational efficiency, splicing, mRNA stability, and RNA nuclear export. All eukaryotic cellular mRNAs are blocked at their 5-prime ends with the 7-methylguanosine cap structure, m7GpppX (where X is any nucleotide). EIF4E is a eukaryotic translation initiation factor involved in directing ribosomes to the cap structure of mRNAs. It is a 24-kD polypeptide that exists as both a free form and as part of a multiprotein complex termed EIF4F. The EIF4E polypeptide is the rate-limiting component of the eukaryotic translation apparatus and is involved in the mRNA-ribosome binding step of eukaryotic protein synthesis. The other subunits of EIF4F are a 50-kD polypeptide, termed EIF4A, that possesses ATPase and RNA helicase activities, and a 220-kD polypeptide, EIF4G.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: eIF-4E; eIF-4F 25 kDa subunit; Eukaryotic translation initiation factor 4E; eukaryotic translation initiation factor 4E-like 1; MGC111573; mRNA cap-binding protein; OTTHUMP00000219703; OTTHUMP00000219704; OTTHUMP00000219705; unnamed protein product
Gene Aliases: AUTS19; CBP; eIF-4E; EIF4E; EIF4E1; EIF4EL1; EIF4F
UniProt ID: (Human) P06730
Entrez Gene ID: (Human) 1977
G1/S transition of mitotic cell cycle
behavioral fear response
mRNA export from nucleus
translation
translational initiation
regulation of translation
negative regulation of autophagy
negative regulation of translation
stem cell population maintenance
neuron differentiation
negative regulation of neuron differentiation
positive regulation of mitotic cell cycle
mRNA transport
nuclear export
cellular response to dexamethasone stimulus
regulation of translation at postsynapse, modulating synaptic transmission
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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