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Proteintech
SUZ12 Polyclonal Antibody
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Product Details
20366-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Rat
Published species
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Peptide
Conjugate
Form
Liquid
Concentration
0.26 mg/mL
Amount
39 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Target Information
SUZ12 (polycomb protein SUZ12) is a zinc finger gene and has been identified at the breakpoints of a recurrent chromosomal translocation reported in endometrial stromal sarcoma. Recombination of these breakpoints results in the fusion of this gene and JAZF1. SUZ12 is also a component of the PRC2/EED-EZH2 complex which methylates Lys-9 (H3K9me) and Lys-27 (H3K27me) of histone H3 leading to transcriptional repression of the affected target gene. The protein encoded by this gene contains a zinc finger domain in the C terminus of the coding region.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: ChET 9 protein; Chromatin precipitated E2F target 9 protein; Joined to JAZF1 protein; KIAA0160; Polycomb protein SUZ12; Suppressor of zeste 12 protein homolog; SUZ12 polycomb repressive complex 2 subunit; unnamed protein product
Gene Aliases: CHET9; IMMAS; JJAZ1; KIAA0160; SUZ12
UniProt ID: (Human) Q15022
Entrez Gene ID: (Human) 23512, (Rat) 688041
RNA polymerase II core promoter proximal region sequence-specific DNA binding
transcription corepressor binding
chromatin binding
RNA binding
protein binding
enzyme activator activity
zinc ion binding
chromatin DNA binding
sequence-specific DNA binding
metal ion binding
histone H3K9me2/3 reader activity
lncRNA binding
promoter-specific chromatin binding
methylated histone binding
histone methyltransferase activity
chromatin/chromatin-binding, or -regulatory protein
negative regulation of transcription from RNA polymerase II promoter
chromatin organization
cell proliferation
positive regulation of cell proliferation
negative regulation of cell differentiation
oligodendrocyte differentiation
random inactivation of X chromosome
facultative heterochromatin formation
histone methylation
histone ubiquitination
spinal cord development
response to retinoic acid
negative regulation of chemokine production
negative regulation of tyrosine phosphorylation of Stat3 protein
negative regulation of epithelial cell proliferation
histone H3-K27 trimethylation
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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