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BIN1 Monoclonal Antibody (12A1)
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Product Details
209-301-E62S
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Mouse
/ IgG1
Class
Monoclonal
Type
Antibody
Clone
12A1
Immunogen
Anti-BIN1 (MOUSE) Monoclonal Antibody was produced in mouse by repeated immunizations with 12A exon BIN1 protein followed by hybridoma development.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Amount
25 µg
Purification
Protein A
Storage buffer
0.02M potassium phosphate, pH 7.2, with 0.15M NaCl
Contains
0.01% sodium azide
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
Product Specific Information
Store vial at -20° C prior to opening. Aliquot contents and freeze at -20° C or below for extended storage. Avoid cycles of freezing and thawing. Centrifuge product if not completely clear after standing at room temperature. This product is stable for several weeks at 4° C as an undiluted liquid. Dilute only prior to immediate use.
This antibody is specific for human BIN1 protein. A BLAST analysis was used to suggest cross-reactivity with BIN1 from human sources based on 100% homology with the immunizing sequence. Cross-reactivity with BIN1 from other sources has not been determined.
Target Information
This gene encodes several isoforms of a nucleocytoplasmic adaptor protein, one of which was initially identified as a MYC-interacting protein with features of a tumor suppressor. Isoforms that are expressed in the central nervous system may be involved in synaptic vesicle endocytosis and may interact with dynamin, synaptojanin, endophilin, and clathrin. Isoforms that are expressed in muscle and ubiquitously expressed isoforms localize to the cytoplasm and nucleus and activate a caspase-independent apoptotic process. Studies in mouse suggest that this gene plays an important role in cardiac muscle development. Alternate splicing of the gene results in ten transcript variants encoding different isoforms. Aberrant splice variants expressed in tumor cell lines have also been described.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: AMPH 2; amphiphysin 2; amphiphysin I homolog; Amphiphysin II; amphiphysin isoform II; subtype 2; amphiphysin-like; Amphiphysin-like protein; box dependant MYC interacting protein 1; Box-dependent myc-interacting protein 1; Bridging integrator 1; DKFZp547F068; MGC10367; MGC105358; Myc box-dependent-interacting protein 1; unnamed protein product
Gene Aliases: AMPH2; AMPHL; BIN1; CNM2; SH3P9
UniProt ID: (Human) O00297
Entrez Gene ID: (Human) 274
negative regulation of transcription from RNA polymerase II promoter
endocytosis
nucleus organization
cytoskeleton organization
endosome to lysosome transport
regulation of cell cycle process
regulation of endocytosis
cell differentiation
positive regulation of actin filament polymerization
T-tubule organization
positive regulation of apoptotic process
regulation of neuron differentiation
positive regulation of endocytosis
synaptic vesicle endocytosis
positive regulation of astrocyte differentiation
establishment of localization in cell
lipid tube assembly
regulation of heart rate by cardiac conduction
negative regulation of potassium ion transmembrane transport
negative regulation of beta-amyloid formation
negative regulation of ventricular cardiac muscle cell action potential
negative regulation of calcium ion transmembrane transport via high voltage-gated calcium channel
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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