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ER-beta-1 (Estrogen Receptor beta-1) Monoclonal Antibody (ERb455), PE

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ER-beta-1 (Estrogen Receptor beta-1) Monoclonal Antibody (ERb455), PE

Product Details

2100-MSM1-PE-100T

Applications
Tested Dilution
Publications

Immunocytochemistry (ICC/IF)

1:50-1:100
-

Flow Cytometry (Flow)

5 µL/10^6 cells
-
Product Specifications

Species Reactivity

Horse, Human, Mouse, Non-human primate, Sheep, Pig, Rat

Host/Isotype

Mouse / IgG2a, kappa

Class

Monoclonal

Type

Antibody

Clone

ERb455

Immunogen

C-terminus fragment of recombinant human estrogen receptor beta protein
3D Epitope / Immunogen

Conjugate

PE PE PE

Excitation/Emission Max

565/576 nm View spectra spectra

Form

Liquid

Concentration

100 µg/mL

Amount

50 µg

Purification

Protein A/G

Storage buffer

PBS, pH 7.4, with 0.05% BSA

Contains

0.05% sodium azide

Storage conditions

4°C, store in dark, DO NOT FREEZE!

Shipping conditions

Ambient (domestic); Wet ice (international)

Target Information

Estrogen Receptor beta (ER beta, NR3A2) protein is approximately 55kD, though multiple isoforms ranging from 36-59kD have been described. Human ER beta was initially cloned and characterized from testis. Estrogen Receptors (ER) are members of the steroid/thyroid hormone receptor superfamily of nuclear receptors. The estrogen receptor is a ligand-activated transcription factor, that when bound to estrogen hormone, induces a conformational change that allows dimerization and binding to estrogen response elements (ERE) in DNA. When bound to EREs, ER can positively or negatively regulate gene transcription through the recruitment of coactivator or corepressor proteins. There are two different forms of the estrogen receptor, alpha and beta, encoded by separate genes (ESR1 and ESR2, respectively). Estrogen receptor beta (ER beta) binds estrogens with an affinity similar to that of estrogen receptor alpha. Some ER beta isoforms dominantly inhibit the activity of estrogen receptor alpha in reproductive tissues. ER beta is found widely in many tissues throughout the body and can act as a potent tumor suppressor, playing a crucial role in many cancer types such as prostate cancer, autism spectrum disorder, medullary thyroid carcinoma, De Quervain Disease and risk of cardiovascular disease.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: ER; ER beta; ER-beta; ERbeta 4; estradiol receptor beta; estrogen receptor 2 (ER beta); estrogen receptor 2 beta; Estrogen receptor beta; estrogen receptor beta 2; estrogen receptor beta 4; nuclear receptor; Nuclear receptor subfamily 3 group A member 2; oestrogen receptor beta; splice variant; steroid receptor; unnamed protein product

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Gene Aliases: er; ER-BETA; ER2; ER[b]; ERB; Erb2; ERBETA; ESR-BETA; ESR2; ESRB; ESTRB; NR3A2; ODG8

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UniProt ID: (Pig) Q9XSW2, (Human) Q92731, (Sheep) Q9TU15, (Mouse) O08537, (Rat) Q62986

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Entrez Gene ID: (Pig) 396697, (Human) 2100, (Horse) 100033964, (Sheep) 443066, (Mouse) 13983, (Rat) 25149

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Function(s)
RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding steroid binding zinc ion binding estrogen receptor activity sequence-specific DNA binding RNA polymerase II core promoter proximal region sequence-specific DNA binding RNA polymerase II transcription factor activity, sequence-specific DNA binding DNA binding transcription factor activity, sequence-specific DNA binding steroid hormone receptor activity protein binding lipid binding enzyme binding estrogen response element binding metal ion binding receptor antagonist activity core promoter sequence-specific DNA binding transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding drug binding hormone binding peroxisome proliferator activated receptor binding estradiol binding steroid hormone binding
Process(es)
negative regulation of transcription from RNA polymerase II promoter ovarian follicle development behavioral fear response neuron migration transcription, DNA-templated regulation of transcription, DNA-templated transcription from RNA polymerase II promoter brain development learning or memory negative regulation of cell proliferation hormone-mediated apoptotic signaling pathway intracellular steroid hormone receptor signaling pathway intracellular estrogen receptor signaling pathway response to testosterone regulation of cell proliferation positive regulation of apoptotic process steroid hormone mediated signaling pathway regulation of neuron apoptotic process estrous cycle positive regulation of epidermal growth factor receptor signaling pathway positive regulation of transcription, DNA-templated positive regulation of transcription from RNA polymerase II promoter negative regulation of behavior negative regulation of smooth muscle cell proliferation negative regulation of epithelial cell proliferation positive regulation of sequence-specific DNA binding transcription factor activity Sertoli cell proliferation uterus development vagina development negative regulation of cell death prostate gland epithelium morphogenesis epithelial cell maturation involved in prostate gland development negative regulation of androgen receptor signaling pathway positive regulation of ERK1 and ERK2 cascade negative regulation of neuron death negative regulation of feeding behavior negative regulation of reactive oxygen species metabolic process cellular response to estradiol stimulus regulation of transcription from RNA polymerase II promoter signal transduction cell-cell signaling negative regulation of cell growth cellular response to oxygen-containing compound male gonad development female gonad development response to water deprivation response to hormone response to organic cyclic compound response to activity response to insecticide cerebellum development amygdala development hypothalamus development prostate gland development response to nutrient levels response to estradiol response to genistein cellular response to drug response to drug response to estrogen response to human chorionic gonadotropin response to ethanol Sertoli cell development cellular response to magnetism cellular response to organic cyclic compound response to dexamethasone response to salt response to bisphenol A
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