Search
Proteintech
GIYD2 Polyclonal Antibody
{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.promotions']}}
{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.viewpromo']}}
{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.promocode']}}: {{promo.promoCode}} {{promo.promoTitle}} {{promo.promoDescription}}. {{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.learnmore']}}
Additional Information:
{{banner.description}}
Product Details
21158-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
GIYD2 Fusion Protein Ag13094 (1-275 aa encoded by BC000803)
Conjugate
Form
Liquid
Concentration
0.39 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
Immunogen sequence: MGPAGVAAR PGRFFGVYLL YCLNPRYRGR VYVGFTVNTA RRVQQHNGGR KKGGAWRTSG RGPWEMVLVV HGFPSSVAAL RFEWAWQHPH ASRRLAHVGP RLRGETAFAF HLRVLAHMLR APPWARLPLT LRWVRPDLRQ DLCLPPPPHV PLAFGPPPPQ APAPRRRAGP FDDAEPEPDQ GDPGACCSLC AQTIQDEEGP LCCPHPGCLL RAHVICLAEE FLQEEPGQLL PLEGQCPCCE KSLLWGDLIW LCQMDTEKEV EDSELEEAHW TDLLET (1-275 aa encoded by B C000803)
Target Information
This gene encodes a protein that is an important regulator of genome stability. The protein represents the catalytic subunit of the SLX1-SLX4 structure-specific endonuclease, which can resolve DNA secondary structures that are formed during repair and recombination processes. Two identical copies of this gene are located on the p arm of chromosome 16 due to a segmental duplication; this record represents the more telomeric copy. Alternative splicing results in multiple transcript variants. Read-through transcription also occurs between this gene and the downstream SULT1A4 (sulfotransferase family, cytosolic, 1A, phenol-preferring, member 4) gene.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: GIY-YIG domain containing 2; GIY-YIG domain-containing protein 1; SLX1 homolog B; SLX1 structure-specific endonuclease subunit homolog B; Structure-specific endonuclease subunit SLX1; unnamed protein product
Gene Aliases: 1110030E23Rik; 2410170E21Rik; 4833422P03Rik; AI853643; GIYD1; GIYD2; SLX1; SLX1A; SLX1B
UniProt ID: (Human) Q9BQ83, (Mouse) Q8BX32
Entrez Gene ID: (Human) 79008, (Mouse) 75764
nuclease activity
endonuclease activity
protein binding
zinc ion binding
crossover junction endodeoxyribonuclease activity
hydrolase activity
5'-flap endonuclease activity
metal ion binding
phosphoric ester hydrolase activity
T/G mismatch-specific endonuclease activity
retroviral 3' processing activity
endodeoxyribonuclease
double-strand break repair via homologous recombination
DNA repair
DNA recombination
cellular response to DNA damage stimulus
DNA double-strand break processing involved in repair via single-strand annealing
telomere maintenance via telomere lengthening
regulation of telomere maintenance
telomeric D-loop disassembly
t-circle formation
negative regulation of telomere maintenance via telomere lengthening
positive regulation of t-circle formation
DNA metabolic process
nucleic acid phosphodiester bond hydrolysis
Disclaimer
Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
Learn more
We're here to help
Get expert recommendations for common problems or connect directly with an on staff expert for technical assistance related to applications, equipment and general product use.
Contact tech support