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Proteintech
LIN7A Polyclonal Antibody
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Product Details
25150-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
LIN7A Fusion Protein Ag18440 (1-90 aa encoded by BC118609)
Conjugate
Form
Liquid
Concentration
0.33 mg/mL
Amount
49.5 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
Immunogen sequence: MLKPSVTSA PTADMATLTV VQPLTLDRDV ARAIELLEKL QESGEVPVHK LQSLKKVLQS EFCTAIREVY QYMHETITVN GCPEFRARAT A (1-90 aa encoded by BC118609)
Target Information
Plays a role in establishing and maintaining the asymmetric distribution of channels and receptors at the plasma membrane of polarized cells. Forms membrane-associated multiprotein complexes that may regulate delivery and recycling of proteins to the correct membrane domains. The tripartite complex composed of LIN7 (LIN7A, LIN7B or LIN7C), CASK and APBA1 may have the potential to couple synaptic vesicle exocytosis to cell adhesion in brain. Ensures the proper localization of GRIN2B (subunit 2B of the NMDA receptor) to neuronal postsynaptic density and may function in localizing synaptic vesicles at synapses where it is recruited by beta-catenin and cadherin. Required to localize Kir2 channels, GABA transporter (SLC6A12) and EGFR/ERBB1, ERBB2, ERBB3 and ERBB4 to the basolateral membrane of epithelial cells.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: hLin-7; lin 7 homolog a; lin-7-Ba; Lin-7A; LIN7A; MALS-1; mammalian LIN-7 1; Mammalian lin-seven protein 1; mLin-7; Protein lin-7 homolog A; similar to Caenorhabditis elegans LIN-7; Tax interaction protein 33; TIP-33; unnamed protein product; Veli-1; veli-1 protein; vertebrate homolog of C. elegans Lin-7 type 1; Vertebrate lin-7 homolog 1; vertebrate LIN7 homolog 1
Gene Aliases: AI848705; LIN-7A; LIN7; LIN7A; MALS-1; MALS1; TIP-33; Veli; VELI1
UniProt ID: (Human) O14910, (Mouse) Q8JZS0
Entrez Gene ID: (Human) 8825, (Mouse) 108030, (Rat) 85327
exocytosis
neurotransmitter secretion
regulation of synaptic growth at neuromuscular junction
protein transport
synaptic vesicle transport
inner ear development
protein-containing complex assembly
transport
asymmetric protein localization
maintenance of epithelial cell apical/basal polarity
protein localization to basolateral plasma membrane
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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