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NeoBiotechnologies
Ku (p70/p80) (Nuclear Marker) Monoclonal Antibody (KU729), PE
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Product Details
2547-MSM1-PE-100T
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Non-human primate
Host/Isotype
Mouse
/ IgG1, kappa
Class
Monoclonal
Type
Antibody
Clone
KU729
Immunogen
Nuclear extract of human HL-60 cells
Conjugate
Excitation/Emission Max
565/576 nm
View spectra
Form
Liquid
Concentration
100 µg/mL
Amount
50 µg
Purification
Protein A/G
Storage buffer
PBS, pH 7.4, with 0.05% BSA
Contains
0.05% sodium azide
Storage conditions
4°C, store in dark, DO NOT FREEZE!
Shipping conditions
Ambient (domestic); Wet ice (international)
Product Specific Information
Does not react with Mouse, Rat or Chicken
Target Information
The protein encoded by this gene is the 80-kilodalton subunit of the Ku heterodimer protein which is also known as ATP-dependant DNA helicase II or DNA repair protein XRCC5. Ku is the DNA-binding component of the DNA-dependent protein kinase, and it functions together with the DNA ligase IV-XRCC4 complex in the repair of DNA double-strand break by non-homologous end joining and the completion of V(D)J recombination events. This gene functionally complements Chinese hamster xrs-6, a mutant defective in DNA double-strand break repair and in ability to undergo V(D)J recombination. A rare microsatellite polymorphism in this gene is associated with cancer in patients of varying radiosensitivity. [provided by RefSeq, Jul 2008].
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: 5'-deoxyribose-5-phosphate lyase Ku70; 5'-dRP lyase Ku70; 70 kDa subunit of Ku antigen; 86 kDa subunit of Ku antigen; ATP-dependent DNA helicase 2 subunit 1; ATP-dependent DNA helicase 2 subunit 2; ATP-dependent DNA helicase II 70 kDa subunit; ATP-dependent DNA helicase II 80 kDa subunit; ATP-dependent DNA helicase II, 70 kDa subunit; CTC box binding factor 75 kDa subunit; CTC box-binding factor 75 kDa subunit; CTC box-binding factor 85 kDa subunit; CTC75; CTC85; CTCBF; DNA repair protein Ku70; DNA repair protein Ku80; DNA repair protein XRCC5; DNA repair protein XRCC6; G22P1; Ku (p70/p80) subunit; Ku antigen; Ku autoantigen p70 subunit; Ku autoantigen, 70kDa; Ku autoantigen, 80kDa; Ku protein subunit; Ku70; Ku80; Ku86; Ku86 autoantigen related protein 1; Lupus Ku autoantigen protein p70; Lupus Ku autoantigen protein p86; Nuclear factor IV; p70 autoantigen; thyroid autoantigen; thyroid autoantigen 70kD (Ku antigen); thyroid autoantigen 70kDa (Ku antigen); Thyroid-lupus autoantigen; thyroid-lupus autoantigen p70; TLAA; unnamed protein product; X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining); X-ray repair complementing defective repair in Chinese hamster cells 6; X-ray repair cross-complementing protein 5; X-ray repair cross-complementing protein 6
Gene Aliases: CTC75; CTCBF; G22P1; G22P2; KARP-1; KARP1; KU70; KU80; Ku86; KUB2; ML8; NFIV; TLAA; XRCC5; XRCC6
UniProt ID: (Human) P13010, (Human) P12956
Entrez Gene ID: (Human) 7520, (Human) 2547
nucleotide binding
transcription regulatory region sequence-specific DNA binding
DNA binding
DNA helicase activity
damaged DNA binding
double-stranded DNA binding
double-stranded telomeric DNA binding
RNA binding
helicase activity
protein binding
ATP binding
enzyme activator activity
DNA-dependent ATPase activity
hydrolase activity
ATPase activity
ubiquitin protein ligase binding
U3 snoRNA binding
telomeric DNA binding
macromolecular complex binding
DNA end binding
5'-deoxyribose-5-phosphate lyase activity
catalytic activity
lyase activity
cyclin binding
scaffold protein binding
telomere maintenance
recombinational repair
activation of innate immune response
immune system process
positive regulation of immune system process
DNA repair
double-strand break repair via nonhomologous end joining
DNA recombination
cellular response to DNA damage stimulus
response to ionizing radiation
negative regulation of macromolecule biosynthetic process
innate immune response
positive regulation of lymphocyte differentiation
positive regulation of protein kinase activity
negative regulation of transcription, DNA-templated
positive regulation of transcription, DNA-templated
positive regulation of transcription from RNA polymerase II promoter
regulation of smooth muscle cell proliferation
cellular hyperosmotic salinity response
cellular response to gamma radiation
cellular response to X-ray
double-strand break repair via classical nonhomologous end joining
double-strand break repair
telomere maintenance via telomerase
neurogenesis
regulation of telomere maintenance
small-subunit processome assembly
ribosome biogenesis
positive regulation of neurogenesis
hematopoietic stem cell differentiation
protein localization to chromosome, telomeric region
hematopoietic stem cell proliferation
negative regulation of t-circle formation
cellular response to leukemia inhibitory factor
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