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NeoBiotechnologies

Interleukin-7 (IL-7) Monoclonal Antibody (IL7/4013)

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Interleukin-7 (IL-7) Monoclonal Antibody (IL7/4013)

Product Details

3574-MSM3-P1

Applications
Tested Dilution
Publications

Immunohistochemistry (Paraffin) (IHC (P))

Assay-dependent
-

Immunohistochemistry (PFA fixed) (IHC (PFA))

1-2 µg/mL
-

Immunocytochemistry (ICC/IF)

1-2 µg/mL
-

Flow Cytometry (Flow)

1-2 µg/10^6 cells
-

Peptide Array (Array)

Assay-dependent
-
Product Specifications

Species Reactivity

Human

Host/Isotype

Mouse / IgG1, kappa

Class

Monoclonal

Type

Antibody

Clone

IL7/4013

Immunogen

Recombinant fragment (around aa 27-177) corresponding to mature protein of human IL7(exact sequence is proprietary)
3D Epitope / Immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

200 µg/mL

Amount

100 µg

Purification

Protein A/G

Storage buffer

PBS, pH 7.4, with 0.05% BSA

Contains

0.05% sodium azide

Storage conditions

4°C, do not freeze

Shipping conditions

Ambient (domestic); Wet ice (international)

Target Information

Interleukin 7 (IL-7) is a hematopoietic cytokine that is constitutively produced by stromal cells from the bone marrow and thymus. IL-7 signals through the IL-7R to promote the differentiation of hematopoietic stem cells to lymphoid precursor cells, which give rise to T cells, B cells, and natural killer cells.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: CD127; CD127 antigen; CDw127; cytokine; H-IL-7; IL-7; IL-7 receptor subunit alpha; IL-7R subunit alpha; IL7R; IL-7 receptor alpha chain; ILN; Interleukin; interleukin 7 precursor; interleukin 7 receptor alpha chain; Interleukin-7; interleukin-7 receptor precursor; Interleukin-7 receptor subunit alpha; Interleukin7; M-IL-7; soluble interleukin-7 receptor; unnamed protein product

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Gene Aliases: CD127; CDW127; IL-7; IL-7R-alpha; IL-7Ralpha; IL7; IL7R; IL7RA; IL7Ralpha; ILRA; IMD104; IMD130; lnc-IL7R; sIL-7R

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UniProt ID: (Human) P13232, (Human) P16871

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Entrez Gene ID: (Human) 3574, (Human) 3575

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Function(s)
cytokine activity cytokine receptor binding interleukin-7 receptor binding protein binding growth factor activity antigen binding cytokine receptor activity interleukin-7 receptor activity
Process(es)
positive regulation of cytokine-mediated signaling pathway T cell lineage commitment immune response humoral immune response cell-cell signaling positive regulation of cell proliferation organ morphogenesis regulation of gene expression positive regulation of gene expression cytokine-mediated signaling pathway cellular homeostasis positive regulation of B cell proliferation positive regulation of chemokine production organ growth interleukin-7-mediated signaling pathway B cell proliferation negative regulation of apoptotic process bone resorption positive regulation of B cell differentiation positive regulation of T cell differentiation positive regulation of organ growth homeostasis of number of cells within a tissue extrinsic apoptotic signaling pathway negative regulation of extrinsic apoptotic signaling pathway negative regulation of extrinsic apoptotic signaling pathway in absence of ligand regulation of DNA recombination cell morphogenesis B cell homeostasis T cell mediated cytotoxicity negative regulation of T cell mediated cytotoxicity signal transduction cell surface receptor signaling pathway regulation of cell size gene expression hemopoiesis T cell differentiation T cell differentiation in thymus positive regulation of T cell differentiation in thymus T cell homeostasis positive regulation of JAK-STAT cascade lymph node development defense response to Gram-positive bacterium negative regulation of T cell apoptotic process positive regulation of STAT cascade
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If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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