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Invitrogen
KPNA1 Monoclonal Antibody (114-E12)
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FIGURE: 1 / 4
KPNA1 Antibody (37-0800) in WB
Western blot analysis was performed on whole cell extracts (30 µg lysate) of HEL 92.1.7 (Lane 1), K-562 (Lane 2), U-2 OS (Lane 3), Caco-2 (Lane 4) and PC-3 (Lane 5). The blot was probed with Anti-NPI 1 Mouse Monoclonal Antibody (Product # 37-0800, 2 µg/mL) and detected by chemiluminescence using Goat anti-Mouse IgG (H+L) Superclonal™ Secondary Antibody, HRP conjµgate (Product # A28177, 0.4 µg/mL, 1:2500 dilution). A ~60 kDa band corresponding to NPI 1 was observed across the cell lines tested. Known quantity of protein samples were electro... View More
Product Details
37-0800
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse
Published species
Human
Host/Isotype
Mouse
/ IgG1
Class
Monoclonal
Type
Antibody
Clone
114-E12
Immunogen
GST fusion protein.
Conjugate
Form
Liquid
Concentration
0.5 mg/mL
Amount
100 µg
Purification
Protein A
Storage buffer
PBS, pH 7.4
Contains
0.1% sodium azide
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Target Information
Recombination activating proteins RAG1 and RAG2 regulate and mediate VJ recombination, the process by which genes for immunoglobulins and T-cell receptors are generated. Several other ubiquitously expressed proteins are thought to be recruited in the recombination process. Among these are the genes affected in severe combined immune deficiency and genes involved in ds-DNA break repair. The protein encoded by this gene interacts with RAG1 and may play a role in VJ recombination. Two transcript variants, one protein-coding and the other not, have been found for this gene.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: IMA2; Importin alpha 2; importin alpha 5; Importin alpha P1; Importin alpha-S1; importin subunit alpha-1; Importin subunit alpha-5; importin-alpha-S1; IPOA 1; IPOA1; Karyopherin A2; karyopherin alpha 1 (importin alpha 5); Karyopherin subunit alpha-1; KPNA1; KPNA2; m-importin-alpha-S1; NPI-1; Nucleoprotein interactor 1; RAG cohort 1; RAG cohort protein 2; RCH 1; RCH1; recombination activating gene cohort 2; SRP 1; SRP1 alpha; SRP1 homolog; SRP1-beta; unnamed protein product
Gene Aliases: AW494490; IPOA5; KPNA1; mSRP1; NPI-1; NPI1; RCH2; SRP1
UniProt ID: (Human) P52294, (Mouse) Q60960
Entrez Gene ID: (Human) 3836, (Mouse) 16646
regulation of DNA recombination
protein import into nucleus
NLS-bearing protein import into nucleus
skeletal muscle satellite cell proliferation
satellite cell activation involved in skeletal muscle regeneration
protein transport
regulation of apoptotic process
skeletal muscle tissue regeneration
regulation of canonical Wnt signaling pathway
postsynapse to nucleus signaling pathway
transport
positive regulation of protein import into nucleus
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If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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