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Invitrogen
RPL11 Monoclonal Antibody (3A4A7)
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FIGURE: 1 / 13
RPL11 Antibody (37-3000) in ICC/IF
Immunofluorescence analysis of L11 was performed using 70% confluent log phase U-2 OS cells treated with doxorubicin (2 µg/mL) for 24 hours. The cells were fixed with 4% paraformaldehyde for 10 minutes, permeabilized with 0.1% Triton™ X-100 for 10 minutes, and blocked with 1% BSA for 1 hour at room temperature. The cells were labeled with RPL11 (3A4A7) Mouse Monoclonal Antibody (Product # 37-3000) at 2 µg/mL in 0.1% BSA and incubated for 3 hours at room temperature and then labeled with Goat anti-Mouse IgG (H+L) Superclonal™ Secondary Anti... View More
Product Details
37-3000
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Non-human primate
Published species
Human,
Mouse,
Rat
Host/Isotype
Mouse
/ IgG1
Class
Monoclonal
Type
Antibody
Clone
3A4A7
Immunogen
fusing the mouse myeloma cell-line P3U1 with spleen cells of BALB/c mouse after immunization with human Laminin (1
Conjugate
Form
Liquid
Concentration
0.5 mg/mL
Amount
100 µg
Purification
Affinity chromatography
Storage buffer
PBS, pH 7.4
Contains
0.1% sodium azide
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Target Information
Subunit of the splicing factor SF3B required for 'A' complex assembly formed by the stable binding of U2 snRNP to the branchpoint sequence (BPS) in pre-mRNA. Sequence independent binding of SF3A/SF3B complex upstream of the branch site is essential, it may anchor U2 snRNP to the pre-mRNA. May also be involved in the assembly of the 'E' complex. Belongs also to the minor U12-dependent spliceosome, which is involved in the splicing of rare class of nuclear pre-mRNA intron.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: 60S ribosomal protein L11; cell growth-inhibiting protein 34; CLL-associated antigen KW-12; GIG34; Large ribosomal subunit protein uL5; RP11-223J15.3; unnamed protein product
Gene Aliases: DBA7; GIG34; L11; RPL11; uL5
UniProt ID: (Human) P62913
Entrez Gene ID: (Human) 6135
ribosomal large subunit assembly
cytoplasmic translation
rRNA processing
translation
protein targeting
positive regulation of gene expression
positive regulation of protein binding
negative regulation of proteasomal ubiquitin-dependent protein catabolic process
protein localization to nucleus
ribosomal large subunit biogenesis
protein stabilization
regulation of signal transduction by p53 class mediator
positive regulation of signal transduction by p53 class mediator
negative regulation of ubiquitin protein ligase activity
negative regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process
negative regulation of protein neddylation
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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