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Invitrogen

LXR beta Monoclonal Antibody (K8917)

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LXR beta Monoclonal Antibody (K8917)

Product Details

418400

Applications
Tested Dilution
Publications

Western Blot (WB)

2 µg/mL
-

ELISA (ELISA)

0.1 µg/mL
-

Immunoprecipitation (IP)

Assay-dependent
-
Product Specifications

Species Reactivity

Human

Host/Isotype

Mouse / IgG2a

Class

Monoclonal

Type

Antibody

Clone

K8917

Immunogen

Produced in BALB/c mouse ascites after inoculation with hybridoma of mouse myeloma cells (NS-1) and spleen cells derived from a BALB/c mouse immunized with Baculovirus-expressed recombinant human LXR-beta (2-86 aa).
3D Epitope / Immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Amount

100 µg

Purification

Ammonium sulfate precipitation

Storage buffer

physiological saline

Contains

0.1% sodium azide

Storage conditions

Maintain refrigerated at 2-8°C for up to 1 month. For long term storage store at -20°C

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2532201

Product Specific Information

This antibody specifically recognizes human LXR beta but does not recognize human LXR alpha. This antibody does not cross react with rat LXR beta. Not yet tested in other species.

Target Information

The liver X receptors, LXRA and LXRB, form a subfamily of the nuclear receptor superfamily and are key regulators of macrophage function, controlling transcriptional programs involved in lipid homeostasis and inflammation. The inducible LXRA is highly expressed in liver, adrenal gland, intestine, adipose tissue, macrophages, lung, and kidney, whereas LXRB is ubiquitously expressed. Ligand-activated LXRs form obligate heterodimers with retinoid X receptors and regulate expression of target genes containing LXR response elements.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: liver X nuclear receptor beta; Liver X receptor beta; LX receptor beta; NR1H2; nuclear orphan receptor LXR-beta; Nuclear receptor NER; Nuclear receptor subfamily 1 group H member 2; Oxysterols receptor LXR-beta; steroid hormone-nuclear receptor NER; Ubiquitously-expressed nuclear receptor; unnamed protein product

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Gene Aliases: LXR-b; LXRB; NER; NER-I; NR1H2; RIP15; UNR

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UniProt ID: (Human) P55055

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Entrez Gene ID: (Human) 7376

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Function(s)
RNA polymerase II core promoter proximal region sequence-specific DNA binding RNA polymerase II transcription factor activity, sequence-specific DNA binding transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding DNA binding transcription factor activity, sequence-specific DNA binding RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding protein binding zinc ion binding chromatin DNA binding apolipoprotein A-I receptor binding sequence-specific DNA binding metal ion binding retinoid X receptor binding ATPase binding
Process(es)
negative regulation of transcription from RNA polymerase II promoter regulation of transcription, DNA-templated regulation of transcription from RNA polymerase II promoter lipid metabolic process hormone-mediated signaling pathway positive regulation of gene expression negative regulation of gene expression negative regulation of macrophage derived foam cell differentiation positive regulation of triglyceride biosynthetic process positive regulation of cholesterol efflux regulation of lipid storage positive regulation of lipid storage negative regulation of cholesterol storage cell differentiation intracellular receptor signaling pathway response to nutrient levels negative regulation of lipid transport positive regulation of cholesterol transport phosphatidylcholine acyl-chain remodeling cholesterol homeostasis mRNA transcription from RNA polymerase II promoter positive regulation of fatty acid biosynthetic process negative regulation of proteolysis negative regulation of transcription, DNA-templated positive regulation of transcription, DNA-templated positive regulation of transcription from RNA polymerase II promoter retinoic acid receptor signaling pathway negative regulation of pinocytosis negative regulation of inflammatory response lipid homeostasis negative regulation of interferon-gamma-mediated signaling pathway positive regulation of high-density lipoprotein particle assembly positive regulation of pancreatic juice secretion positive regulation of secretion of lysosomal enzymes negative regulation of cold-induced thermogenesis positive regulation of pri-miRNA transcription from RNA polymerase II promoter negative regulation of response to endoplasmic reticulum stress
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