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Invitrogen

Fibrillarin Monoclonal Antibody (38F3)

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View all (25) Fibrillarin antibodies

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Product Details

480009

Applications
Tested Dilution
Publications

Western Blot (WB)

1:1,000
View 1 publication 1 publication

Immunohistochemistry (IHC)

1:100-1:500
-

Immunocytochemistry (ICC/IF)

1:250-1:500
View 1 publication 1 publication
Product Specifications

Species Reactivity

Bovine, Chicken, Fruit fly, Human, Mouse, Pig, Rat, Yeast

Published species

Human

Host/Isotype

Mouse / IgG1

Class

Monoclonal

Type

Antibody

Clone

38F3

Immunogen

Yeast nuclear preparations.

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Amount

100 µg

Purification

Protein G

Storage buffer

PBS with 50% glycerol

Contains

5mM sodium azide

Storage conditions

-20°C, Avoid Freeze/Thaw Cycles

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2532241

Target Information

Nop1p / Fibrillarin was originally identified as a nucleolar protein of bakers yeast, Saccharomyces cerevisiae (accession P15646). The Nop1p protein is essential for yeast viability and is localized in the nucleoli. The human homologue of Nop1p is fibrillarin (accession P22087) a component of the nucleolar small nuclear ribonucleoprotein (snRNP) particle. The human fibrillarin gene is located on chromosome 19 (19q13. 1).

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Bioinformatics

Protein Aliases: 34 kDa nucleolar scleroderma antigen; 34-kD nucleolar scleroderma antigen; AT20009p; CG5725-PA; CG5725-PB; CG5725-PC; CG5725-PD; CG5725-PE; CG5725-PF; CG5725-PG; FBL; fbl-PA; fbl-PB; fbl-PC; fbl-PD; fbl-PE; fbl-PF; fbl-PG; Histone-glutamine methyltransferase; LD24618p; LP11571p; Nucleolar protein 1; pantothenate kinase; RNA, U3 small nucleolar interacting protein 1; rRNA 2'-O-methyltransferase fibrillarin; U3 small nucleolar RNA-associated protein NOP1; U6 snRNA 2'-O-methyltransferase fibrillarin; unnamed protein product

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Gene Aliases: AL022665; CG5725; D2870; Dmel\CG5725; Dmel_CG5725; dPANK; dPANK/Fbl; FBL; FIB; FIB1; FLRN; LOT3; NOP1; PANK; RNU3IP1; YDL014W

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UniProt ID: (Human) P22087, (Rat) P22509, (Mouse) Q99L58, (Baker's yeast) P15646

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Entrez Gene ID: (Human) 2091, (Pig) 100626002, (Bovine) 538548, (Rat) 292747, (Mouse) 14113, (Baker's yeast) 851548, (Fruit fly) 46234

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Function(s)
TFIID-class transcription factor binding RNA binding protein binding methyltransferase activity rRNA methyltransferase activity transferase activity ATPase binding U6 snRNA 2'-O-ribose methyltransferase activity histone-glutamine methyltransferase activity poly(A) RNA binding rRNA (adenine-N6,N6-)-dimethyltransferase activity protein C-terminal carboxyl O-methyltransferase activity tRNA (guanine-N2-)-methyltransferase activity C-methyltransferase activity N-methyltransferase activity O-methyltransferase activity S-methyltransferase activity RNA methyltransferase activity mRNA methyltransferase activity tRNA methyltransferase activity protein methyltransferase activity 2-polyprenyl-6-methoxy-1,4-benzoquinone methyltransferase activity rRNA (uridine-2'-O-)-methyltransferase activity rRNA (adenine-N6-)-methyltransferase activity DNA-methyltransferase activity tRNA (guanine-N1-)-methyltransferase activity rRNA (cytosine-C5-)-methyltransferase activity selenocysteine methyltransferase activity arginine N-methyltransferase activity protein-arginine N-methyltransferase activity lysine N-methyltransferase activity protein-lysine N-methyltransferase activity tRNA (uracil) methyltransferase activity tRNA (guanine) methyltransferase activity tRNA (adenine) methyltransferase activity tRNA (cytosine) methyltransferase activity tRNA (cytosine-5-)-methyltransferase activity tRNA (adenine-N1-)-methyltransferase activity rRNA (adenine) methyltransferase activity rRNA (cytosine) methyltransferase activity rRNA (guanine) methyltransferase activity rRNA (uridine) methyltransferase activity protein C-terminal leucine carboxyl O-methyltransferase activity 1-phenanthrol methyltransferase activity protein-arginine N5-methyltransferase activity methylarsonite methyltransferase activity dimethylarsinite methyltransferase activity 4,5-dihydroxybenzo(a)pyrene methyltransferase activity 1-hydroxypyrene methyltransferase activity 1-hydroxy-6-methoxypyrene methyltransferase activity demethylmenaquinone methyltransferase activity cobalt-precorrin-6B C5-methyltransferase activity cobalt-precorrin-7 C15-methyltransferase activity cobalt-precorrin-5B C1-methyltransferase activity cobalt-precorrin-3 C17-methyltransferase activity dimethylamine methyltransferase activity hydroxyneurosporene-O-methyltransferase activity tRNA (adenine-57, 58-N(1)-) methyltransferase activity methylamine-specific methylcobalamin:coenzyme M methyltransferase activity trimethylamine methyltransferase activity methanol-specific methylcobalamin:coenzyme M methyltransferase activity monomethylamine methyltransferase activity P-methyltransferase activity Se-methyltransferase activity 2-phytyl-1,4-naphthoquinone methyltransferase activity tRNA (uracil-2'-O-)-methyltransferase activity tRNA (cytosine-2'-O-)-methyltransferase activity phosphomethylethanolamine N-methyltransferase activity tRNA (cytosine-3-)-methyltransferase activity rRNA (cytosine-2'-O-)-methyltransferase activity rRNA (cytosine-N4-)-methyltransferase activity trihydroxyferuloyl spermidine O-methyltransferase activity pantothenate kinase activity ATP binding RNA processing factor kinase transferase metabolite interconversion enzyme
Process(es)
box C/D snoRNA 3'-end processing osteoblast differentiation chromatin remodeling rRNA processing snoRNA metabolic process rRNA methylation methylation ribosomal small subunit biogenesis snoRNA localization RNA processing tRNA processing histone glutamine methylation ribosome biogenesis snoRNA processing mitotic cell cycle response to oxidative stress chromosome segregation spermatogenesis imaginal disc-derived wing morphogenesis coenzyme A biosynthetic process regulation of cytokinesis locomotion locomotor rhythm oogenesis meiotic cell cycle membrane organization triglyceride homeostasis cellular response to gamma radiation
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