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5-HTR3 Polyclonal Antibody
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FIGURE: 1 / 1
5-HTR3 Antibody (BS-24701R) in WB
Lane 1:Mouse Stomach tissue lysates; Lane 2: Rat Spinal cord tissue lysates; Lane 3: Rat Stomach tissue lysates; Lane 4: Rat Small intestine tissue lysates ; Lane 5: Mouse BV2 cell lysates; Lane 6: Human U251 cell lysates; Lane 7: Human SH-SY5Y cell lysates probed with 5-HTR3 Polyclonal Antibody, Unconjugated (bs-24701R) at 1:1000 dilution and 4°C overnight incubation. Followed by conjugated secondary antibody incubation at 1:20000 for 60 min at 37°C.
Product Details
BS-24701R
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
KLH conjugated synthetic peptide derived from human 5-HTR3
Conjugate
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Protein A
Storage buffer
TBS, pH 7.4, with 1% BSA, 50% glycerol
Contains
0.03% ProClin 300
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
Target Information
The product of this gene belongs to the ligand-gated ion channel receptor superfamily. This gene encodes subunit A of the type 3 receptor for 5-hydroxytryptamine, a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. This receptor causes fast, depolarizing responses in neurons after activation. It appears that the heteromeric combination of A and B subunits is necessary to provide the full functional features of this receptor, since either subunit alone results in receptors with very low conductance and response amplitude. Alternatively spliced transcript variants encoding different isoforms have been identified.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: 5-HT-3; 5-HT3 receptor; 5-HT3-A; 5-HT3A; 5-HT3R; 5-HT3R-As; 5-hydroxytryptamine (serotonin) receptor 3A, ionotropic; 5-hydroxytryptamine receptor 3; 5-hydroxytryptamine receptor 3A; 5HT3 serotonin receptor; serotonin receptor; Serotonin receptor 3A; Serotonin-gated ion channel receptor; truncated receptor; unnamed protein product
Gene Aliases: 5-HT-3; 5-HT3; 5-HT3A; 5-HT3R; 5HT3; 5HT3R; HTR3; HTR3A
UniProt ID: (Human) P46098, (Rat) P35563, (Mouse) P23979
Entrez Gene ID: (Human) 3359, (Rat) 79246, (Mouse) 15561
transmembrane signaling receptor activity
ion channel activity
extracellular ligand-gated ion channel activity
excitatory extracellular ligand-gated ion channel activity
protein binding
ligand-gated ion channel activity
serotonin-gated cation channel activity
identical protein binding
serotonin binding
ligand-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential
transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential
G-protein coupled serotonin receptor activity
serotonin-activated cation-selective channel activity
voltage-gated potassium channel activity
ligand-gated ion channel
ion transport
serotonin receptor signaling pathway
chemical synaptic transmission
ion transmembrane transport
regulation of membrane potential
regulation of postsynaptic membrane potential
excitatory postsynaptic potential
inorganic cation transmembrane transport
regulation of presynaptic membrane potential
serotonin-gated cation-selective signaling pathway
cation transport
response to cocaine
response to ethanol
cellular response to growth factor stimulus
potassium ion transmembrane transport
cation transmembrane transport
transport
regulation of ion transmembrane transport
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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