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Invitrogen
CXCL10 Polyclonal Antibody, PeproTech®
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FIGURE: 1 / 3
CXCL10 Antibody (500-P290-1MG) in WB
Western Blot: To detect Rat IP-10 by Western Blot analysis CXCL10 Polyclonal Antibody (Product # 500-P290-1MG) can be used at a concentration of 0.1-0.2 µg/mL. Used in conjunction with compatible secondary reagents the detection limit for Recombinant Rat IP-10 is 1.5-3.0 ng/lane, under either reducing or non-reducing conditions.
Product Details
500-P290-1MG
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Rat
Host/Isotype
Rabbit
Class
Polyclonal
Type
Antibody
Immunogen
E.coli-derived Recombinant Rat IP-10 (CXCL10)
Conjugate
Form
Lyophilized
Concentration
0.1-1.0 mg/mL
Amount
1 mg
Purification
Antigen affinity chromatography
Storage buffer
PBS
Contains
no preservative
Storage conditions
-20°C
Shipping conditions
Ambient
RRID
Product Specific Information
AA Sequence of recombinant protein: IPLARTVRCT CIDFHEQPLR PRAIGKLEII PASLSCPHVE IIATMKKNNE KRCLNPESEA IKSLLKAVSQ RRSKRAP.
Preparation: Produced from sera of rabbits immunized with highly pure Recombinant Rat IP-10 (CXCL10). Anti-Rat IP-10 (CXCL10)-specific antibody was purified by affinity chromatography employing an immobilized Rat IP-10 (CXCL10) matrix.
Sandwich ELISA: To detect Rat IP-10 (CXCL10) by sandwich ELISA (using 100 µL/well antibody solution) a concentration of 0.5-2.0 µg/mL of this antibody is required. This antigen affinity purified antibody, in conjunction with PeproTech Biotinylated Anti-Rat IP-10 (CXCL10) (500-P290Bt) as a detection antibody, allows the detection of at least 0.2-0.4 ng/well of Recombinant Rat IP-10 (CXCL10).
Western Blot: To detect Rat IP-10 by Western Blot analysis this antibody can be used at a concentration of 0.1-0.2 µg/mL. Used in conjunction with compatible secondary reagents the detection limit for Recombinant Rat IP-10 is 1.5-3.0 ng/lane, under either reducing or non-reducing conditions.
Target Information
IP-10 (interferon-gamma induced protein 10 kD; in mouse, also called cytokine responsive gene 2, Crg-2, or mob-1) is a highly inducible, primary response gene that belongs to the CXC chemokine superfamily. It was first cloned in 1985. The biological functions of IP-10 are still unclear. Like Mig, IP-10 has no activity on neutrophils. Its functions include stimulation of monocytes, natural killer and T-cell migration, regulation of T-cell and bone marrow progenitor maturation, modulation of adhesion molecule expression as well as inhibition of angiogenesis. Mig and IP-10 share the same receptor, CXCR3.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: 10 kDa interferon gamma-induced protein; C Cmotif chemokine; C X C motif chemokine; C-X-C motif chemokine 10; CC motif chemokine; CCmotif chemokine; CXC; CXC motif chemokine; CXCL; Gamma-IP10; H-IP-10; interferon-inducible cytokine IP-10; Interferon-inducible protein 10; M-IP-10; Protein Mob-1; small inducible cytokine B subfamily (Cys-X-Cys) member 10; small inducible cytokine B subfamily (Cys-X-Cys), member 10; Small-inducible cytokine B10
Gene Aliases: Cxcl10; Inp10; IP-10; Mob1; Scyb10
UniProt ID: (Rat) P48973
Entrez Gene ID: (Rat) 245920
positive regulation of leukocyte chemotaxis
chemotaxis
inflammatory response
immune response
G-protein coupled receptor signaling pathway
positive regulation of cell proliferation
response to cold
response to virus
response to gamma radiation
T cell chemotaxis
response to auditory stimulus
negative regulation of angiogenesis
positive regulation of cell migration
positive regulation of cAMP metabolic process
response to lipopolysaccharide
response to vitamin D
cellular response to heat
regulation of cell proliferation
positive regulation of cAMP-mediated signaling
negative regulation of myoblast differentiation
positive regulation of release of sequestered calcium ion into cytosol
defense response to virus
chemokine-mediated signaling pathway
cellular response to lipopolysaccharide
negative regulation of myoblast fusion
positive regulation of T cell migration
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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