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Invitrogen
Lymphotactin Polyclonal Antibody, PeproTech®
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FIGURE: 1 / 3
Lymphotactin Antibody (500-P40-50UG) in WB
Western Blot: To detect hLymphotactin by Western Blot analysis Lymphotactin Polyclonal Antibody (Product # 500-P40-1MG) can be used at a concentration of 0.1-0.2 µg/mL. Used in conjunction with compatible secondary reagents the detection limit for Recombinant hLymphotactin is 1.5-3.0 ng/lane, under either reducing or non-reducing conditions.
Product Details
500-P40-50UG
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Published species
Human
Host/Isotype
Rabbit
Class
Polyclonal
Type
Antibody
Immunogen
E.coli-derived Recombinant Human Lymphotactin (XCL1)
Conjugate
Form
Lyophilized
Concentration
0.1-1.0 mg/mL
Amount
50 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS
Contains
no preservative
Storage conditions
-20°C
Shipping conditions
Ambient
RRID
Product Specific Information
AA Sequence of recombinant protein: GSEVSDKRTC VSLTTQRLPV SRIKTYTITE GSLRAVIFIT KRGLKVCADP QATWVRDVVR SMDRKSNTRN NMIQTKPTGT QQSTNTAVTL TG.
Preparation: Produced from sera of rabbits immunized with highly pure Recombinant Human Lymphotactin (XCL1). Anti-Human Lymphotactin (XCL1)-specific antibody was purified by affinity chromatography employing an immobilized Human Lymphotactin (XCL1) matrix.
Sandwich ELISA: To detect Human Lymphotactin (XCL1) by sandwich ELISA (using 100 µL/well antibody solution) a concentration of 0.5-2.0 µg/mL of this antibody is required. This antigen affinity purified antibody, in conjunction with PeproTech Biotinylated Anti-Human Lymphotactin (XCL1) (500-P40Bt) as a detection antibody, allows the detection of at least 0.2-0.4 ng/well of Recombinant Human Lymphotactin (XCL1).
Western Blot: To detect hLymphotactin by Western Blot analysis this antibody can be used at a concentration of 0.1-0.2 µg/mL. Used in conjunction with compatible secondary reagents the detection limit for Recombinant hLymphotactin is 1.5-3.0 ng/lane, under either reducing or non-reducing conditions.
Target Information
Lymphotactin, otherwise known as XCL1, is a member of the C-chemokine family that uniquely acts as a chemoattractant for lymphocytes, but not monocytes or neutrophils, suggesting an important regulatory role in lymphocyte trafficking and inflammation. Lymphotactin, shown to signal through chemokine XC receptor 1 (XCR1), is detected at the highest level in the spleen and at low levels in the lungs, small intestine and colon, and is abundantly and selectively expressed by activated T cells, in particular CD8+ T cells, and is also produced by NK cells.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: ATAC; C motif chemokine 1; chemokine (C motif) ligand 1; Cytokine SCM-1; Lymphotactin; Lymphotaxin; SCM-1-alpha; SCM-1-beta; SCM-1alpha; SCM-1beta; SCM1alpha; SCM1beta; single cysteine motif 1a; small inducible cytokine subfamily C, member 1 (lymphotactin); Small-inducible cytokine C1; XC chemokine ligand 1
Gene Aliases: ATAC; LPTN; LTN; SCM-1; SCM-1a; SCM1; SCM1A; SCYC1; XCL1
UniProt ID: (Human) P47992
Entrez Gene ID: (Human) 6375
positive regulation of T cell mediated cytotoxicity
positive regulation of leukocyte chemotaxis
negative regulation of T cell cytokine production
positive regulation of T cell cytokine production
negative regulation of T-helper 1 type immune response
chemotaxis
inflammatory response
immune response
signal transduction
cell-cell signaling
response to virus
positive regulation of T cell chemotaxis
positive regulation of cell migration
neutrophil chemotaxis
killing of cells of other organism
negative regulation of interferon-gamma production
negative regulation of interleukin-2 production
positive regulation of interleukin-10 production
mature natural killer cell chemotaxis
negative regulation of transcription, DNA-templated
positive regulation of transcription from RNA polymerase II promoter
regulation of inflammatory response
release of sequestered calcium ion into cytosol
positive regulation of release of sequestered calcium ion into cytosol
cell chemotaxis
antimicrobial humoral immune response mediated by antimicrobial peptide
chemokine-mediated signaling pathway
cellular response to interleukin-4
cellular response to transforming growth factor beta stimulus
positive regulation of transforming growth factor beta production
positive regulation of granzyme B production
positive regulation of neutrophil chemotaxis
positive regulation of thymocyte migration
positive regulation of natural killer cell chemotaxis
positive regulation of granzyme A production
negative regulation of T-helper 1 cell activation
positive regulation of B cell chemotaxis
positive regulation of T-helper 2 cell cytokine production
positive regulation of T-helper 1 cell cytokine production
positive regulation of immunoglobulin production in mucosal tissue
negative regulation of CD4-positive, alpha-beta T cell proliferation
positive regulation of CD4-positive, alpha-beta T cell proliferation
positive regulation of CD8-positive, alpha-beta T cell proliferation
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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