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NeoBiotechnologies
Prohibitin Monoclonal Antibody (PHB, 3194)
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Product Details
5245-MSM4-P0
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Mouse
/ IgG2b, kappa
Class
Monoclonal
Type
Antibody
Clone
PHB, 3194
Immunogen
Recombinant human PHB protein fragment (aa167-261)
Conjugate
Form
Liquid
Concentration
200 µg/mL
Amount
20 µg
Purification
Protein A/G
Storage buffer
PBS, pH 7.4, with 0.05% BSA
Contains
0.05% sodium azide
Storage conditions
4°C
Shipping conditions
Ambient (domestic); Wet ice (international)
Product Specific Information
Immunohistochemistry (PFA fixed): incubate antibody for 30 min RT. Staining of formalin-fixed tissues requires heating tissue sections in 10mM Tris with 1mM EDTA, pH 9.0, for 45 min at 95 degrees C followed by cooling at RT for 20 minutes.
Target Information
Prohibitin is from an evolutionarily conserved gene that is ubiquitously expressed. It is thought to be a negative regulator of cell proliferation and may be a tumor suppressor. Mutations in PHB have been linked to sporadic breast cancer. Prohibitin is expressed as two transcripts with varying lengths of 3' untranslated region. The longer transcript is present at higher levels in proliferating tissues and cells, suggesting that this longer 3' untranslated region may function as a trans-acting regulatory RNA.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: epididymis luminal protein 215; epididymis secretory sperm binding protein Li 54e; gastric cancer susceptibility protein; OTTHUMP00000165765; OTTHUMP00000165766; OTTHUMP00000220103; OTTHUMP00000220170; OTTHUMP00000220171; PHB; prohibitin; Prohibitin 1; unnamed protein product
Gene Aliases: BAP32; HEL-215; HEL-S-54e; PHB; PHB1
UniProt ID: (Human) P35232
Entrez Gene ID: (Human) 5245
negative regulation of transcription from RNA polymerase II promoter
osteoblast differentiation
positive regulation of immunoglobulin production
regulation of transcription, DNA-templated
mitochondrion organization
signal transduction
negative regulation of cell proliferation
positive regulation of gene expression
negative regulation of transcription by competitive promoter binding
negative regulation of cell growth
positive regulation of interleukin-17 production
RIG-I signaling pathway
regulation of gene expression, epigenetic
B cell activation
negative regulation of protein catabolic process
regulation of apoptotic process
positive regulation of neuron apoptotic process
modulation by host of viral RNA genome replication
positive regulation of G-protein coupled receptor protein signaling pathway
negative regulation of transcription, DNA-templated
positive regulation of transcription, DNA-templated
positive regulation of complement activation
viral entry into host cell
positive regulation of smooth muscle cell proliferation
protein stabilization
progesterone receptor signaling pathway
positive regulation of protein kinase B signaling
negative regulation of androgen receptor signaling pathway
negative regulation of ERK1 and ERK2 cascade
positive regulation of ERK1 and ERK2 cascade
cellular response to interleukin-6
DNA biosynthetic process
T-helper 17 type immune response
antiviral innate immune response
positive regulation of NIK/NF-kappaB signaling
negative regulation of glucocorticoid receptor signaling pathway
Disclaimer
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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