Immunogen sequence: TISVPSYPSKS ASVTASSESP VEIQNPYLHV EPEKEVVSLV PESLSPEDVG NASTENSDMP APSPGLDYEP EGVPDNSPNL QNNPEEPNPE APHVLDVYLE
Highest antigen sequence identity to the following orthologs - mouse 76%, rat 75%.
Regulator that plays a central role in regulation of apoptosis and cell growth via its interactions. Regulates TP53 by enhancing the DNA binding and transactivation function of TP53 on the promoters of proapoptotic genes in vivo. Inhibits the ability of APPBP1 to conjugate NEDD8 to CUL1, and thereby decreases APPBP1 ability to induce apoptosis. Impedes cell cycle progression at G2/M. Its apoptosis-stimulating activity is inhibited by its interaction with DDX42.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: 53BP2; Apoptosis-stimulating of p53 protein 2; apoptosis-stimulating protein of p53, 2; Bbp; BCL2-binding protein; P PPP1R13A; Renal carcinoma antigen NY-REN-51; tumor protein p53 binding protein, 2; Tumor suppressor p53-binding protein 2
Gene Aliases: 53BP2; ASPP2; BBP; P53BP2; PPP1R13A; TP53BP2
UniProt ID: (Human) Q13625
Entrez Gene ID: (Human) 7159
Molecular Function: protein-binding activity modulator