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Proteintech
NOVA2 Polyclonal Antibody
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Product Details
55002-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Peptide
Conjugate
Form
Liquid
Concentration
0.21 mg/mL
Amount
31.5 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
The antibody is specific to NOVA2.
Target Information
Paraneoplastic opsoclonus myoclonus ataxia (POMA) is a neurologic disorder thought to be mediated by an autoimmune attack against onconeural disease antigens that are expressed by gynecologic or lung tumors and by neurons. Nova-1 and -2 are both POMA disease antigens. The autoimmune attack against Nova-2 in POMA patients results in latent cancer, reduced inhibitory control of movements, and dementia. Nova-2 is closely related to Nova-1, and is expressed at high levels in neurons during development and at lower levels in the adult lung. In the postnatal mouse brain, Nova-2 is expressed in a pattern that is largely reciprocal with Nova-1, including high levels of Nova-2 expression in the neocortex and hippocampus. Both Novas are RNA binding proteins, and Nova-2 binds RNA with high affinity and with sequence specificity that differs from Nova-1. They regulate neuronal pre-messenger RNA splicing by directly binding to RNA. Nova-2 target genes function either in the synapse or in axon guidance indicating that Nova-2 is a major regulator of synaptic function.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: Astrocytic NOVA1-like RNA-binding protein; encodes KH-domain; Neuro-oncological ventral antigen 2; neuro-oncological ventral antigen 3; neuronal KH-type RNA-binding protein; RNA-binding protein Nova-2
Gene Aliases: ANOVA; Gm1424; NEDASB; NOVA-2; NOVA2; NOVA3
UniProt ID: (Human) Q9UNW9, (Mouse) A0A1W2P872
Entrez Gene ID: (Human) 4858, (Rat) 292681, (Mouse) 384569
regulation of alternative mRNA splicing, via spliceosome
mRNA splicing, via spliceosome
mRNA processing
nervous system development
RNA splicing
central nervous system neuron development
neuron differentiation
regulation of RNA metabolic process
negative regulation of cold-induced thermogenesis
regulation of axon guidance
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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