Fabgennix

5HT2A Receptor Polyclonal Antibody, FITC

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5HT2A Receptor Polyclonal Antibody, FITC

Product Details

5HT2A-FITC

Applications
Tested Dilution
Publications

Western Blot (WB)

1:500-1:1,000
-

Immunohistochemistry (IHC)

1:50-1:250
-

ELISA (ELISA)

1:10,000
-

Immunoprecipitation (IP)

1:50-1:250
-
Product Specifications

Species Reactivity

Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Synthetic peptide taken within amino acid region 400-450 on human 5-hydroxytryptamine receptor 2A.
View immunogen

Conjugate

FITC FITC FITC

Excitation/Emission Max

498/517 nm View spectra spectra

Form

Liquid

Concentration

0.5-1.5 mg/mL

Purification

Affinity chromatography

Storage buffer

proprietary buffer, pH 7.4-7.8, with 30% glycerol, 0.5% BSA

Contains

0.02% sodium azide

Storage conditions

-20°C, store in dark

Shipping conditions

Ambient (domestic); Wet ice (international)

Target Information

In platelets and gut, serotonin plays a major role in cardiovascular function and motility of the gastrointestinal tract, respectively. Serotonin mediates its effects through several of G protein coupled receptors, designated 5-HT receptors or alternatively SR receptors. The SR-2 receptors are comprised of three subtypes, SR-2A, SR-2B and SR-2C, which activate phospholipase C and release intracellular stores of calcium in response to serotonin. SR-2A has a specific role in tracheal smooth muscle contraction, bronchoconstriction and mediating aldosterone production, and it is also thought to play a role in several psychiatric disorders, including depression and schizophrenia. SR-2B is expressed in embryonic and adult cardiovascular tissues, gut and brain and plays an important role in the pathology of cardiac disorders. SR-2C is thought to mediate the effects of atypical antipsychotic drugs.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: 5-HT-2; 5-HT-2A; 5-HT2 receptor; 5-HT2A receptor; 5-HT2A/2C; 5-HT2A/2C receptor; 5-hydroxytryptamine (serotonin) receptor 2A, G protein-coupled; 5-hydroxytryptamine 2 receptor; 5-hydroxytryptamine receptor 2A; 5HT2A Receptor; serotonin 5-HT-2A receptor; serotonin 5HT-2 receptor; Serotonin receptor 2A; SR2A

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Gene Aliases: 5-HT2A; 5Ht-2; E030013E04; Htr-2; HTR2; HTR2A

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UniProt ID: (Human) P28223, (Mouse) P35363, (Rat) P14842

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Entrez Gene ID: (Human) 3356, (Mouse) 15558, (Rat) 29595

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Function(s)
virus receptor activity G-protein alpha-subunit binding G-protein coupled serotonin receptor activity drug binding protein complex binding serotonin binding 1-(4-iodo-2,5-dimethoxyphenyl)propan-2-amine binding signal transducer activity G-protein coupled receptor activity protein binding G-protein coupled receptor
Process(es)
temperature homeostasis cellular calcium ion homeostasis activation of phospholipase C activity phospholipase C-activating serotonin receptor signaling pathway serotonin receptor signaling pathway chemical synaptic transmission aging memory cell death positive regulation of cell proliferation positive regulation of phosphatidylinositol biosynthetic process regulation of dopamine secretion phosphatidylinositol 3-kinase signaling artery smooth muscle contraction urinary bladder smooth muscle contraction sleep response to drug negative regulation of potassium ion transport positive regulation of MAP kinase activity protein localization to cytoskeleton positive regulation of fat cell differentiation positive regulation of glycolytic process positive regulation of vasoconstriction viral entry into host cell regulation of hormone secretion behavioral response to cocaine positive regulation of peptidyl-tyrosine phosphorylation regulation of behavior detection of temperature stimulus involved in sensory perception of pain detection of mechanical stimulus involved in sensory perception of pain release of sequestered calcium ion into cytosol negative regulation of synaptic transmission, glutamatergic positive regulation of ERK1 and ERK2 cascade smooth muscle contraction signal transduction G-protein coupled receptor signaling pathway positive regulation of cytosolic calcium ion concentration behavior sensory perception of pain positive regulation of kinase activity
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