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5HT2B R Polyclonal Antibody
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Product Details
OSS00189W-100UL
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ Ig
Class
Polyclonal
Type
Antibody
Immunogen
A synthetic peptide from aa region 380-430 of human 5HT2B receptor conjugated to blue carrier protein was used as the antigen
Conjugate
Form
Lyophilized
Concentration
Conc. Not Determined
Storage buffer
whole serum
Contains
no preservative
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. Glycerol (1:1) may be added for added stability.
Shipping conditions
Ambient (domestic); Wet ice (international)
Product Specific Information
Reconstitute in 100 µL of sterile water. Centrifuge to remove any insoluble material.
Specificity of this antibody: 5HT2B receptor.
Target Information
HTR2B is a g-protein coupled receptor for 5-hydroxytryptamine (serotonin). It functions as a receptor for various ergot alkaloid derivatives and psychoactive substances. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors. HTR2B also plays a role in perception of pain, regulation of behavior. It is required to normal proliferation of embryonic cardiac myocytes and normal heart development.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: 5-HT 2B receptor; 5-HT-2B; 5-HT2b receptor; 5-hydroxytryptamine (serotonin) receptor 2B, G protein-coupled; 5-hydroxytryptamine 2B receptor; 5-hydroxytryptamine receptor 2B; 5HT2B Receptor; serotonin; Serotonin receptor 2B; unnamed protein product
Gene Aliases: 5-HT(2B); 5-HT-2B; 5-HT2B; HTR2B
UniProt ID: (Human) P41595
Entrez Gene ID: (Human) 3357
neural crest cell migration
positive regulation of cytokine production
positive regulation of endothelial cell proliferation
heart morphogenesis
cardiac muscle hypertrophy
cellular calcium ion homeostasis
smooth muscle contraction
signal transduction
G-protein coupled receptor signaling pathway
G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger
phospholipase C-activating serotonin receptor signaling pathway
serotonin receptor signaling pathway
chemical synaptic transmission
heart development
positive regulation of cell proliferation
response to xenobiotic stimulus
positive regulation of phosphatidylinositol biosynthetic process
neural crest cell differentiation
intestine smooth muscle contraction
calcium-mediated signaling
cGMP-mediated signaling
vasoconstriction
negative regulation of apoptotic process
positive regulation of I-kappaB kinase/NF-kappaB signaling
embryonic morphogenesis
regulation of behavior
release of sequestered calcium ion into cytosol
positive regulation of cell division
ERK1 and ERK2 cascade
positive regulation of ERK1 and ERK2 cascade
G protein-coupled serotonin receptor signaling pathway
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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