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Fabgennix
5HT2C Receptor Polyclonal Antibody
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Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
Product Details
5HT2C-301AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Non-human primate,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Synthetic peptide taken within amino acid region 400-458 on human 5-hydroxytryptamine receptor 2C.
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Liquid
Concentration
0.5-1.5 mg/mL
Purification
Affinity chromatography
Storage buffer
proprietary buffer, pH 7.4-7.8, with 0.5% BSA, 30% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
Target Information
Serotonin (5-hydroxytryptamine, 5-HT), a neurotransmitter, elicits a wide array of physiological effects by binding to several receptor subtypes, including the 5-HT2 family of seven-transmembrane-spanning, G-protein-coupled receptors, which activate phospholipase C and D signaling pathways. This gene encodes the 2C subtype of serotonin receptor and its mRNA is subject to multiple RNA editing events, where genomically encoded adenosine residues are converted to inosines. RNA editing is predicted to alter amino acids within the second intracellular loop of the 5-HT2C receptor and generate receptor isoforms that differ in their ability to interact with G proteins and the activation of phospholipase C and D signaling cascades, thus modulating serotonergic neurotransmission in the central nervous system. Studies in humans have reported abnormalities in patterns of 5-HT2C editing in depressed suicide victims.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: 5-HT-1C; 5-HT1C; 5-HT1c receptor; 5-HT2C receptor; 5-hydroxytryptamine (serotonin) receptor 2C, G protein-coupled; 5-hydroxytryptamine receptor 1C; 5HT2C Receptor; HGNC:5295; RP11-810O3.1; RP23-15B7.1; serotonin; serotonin 1c receptor; serotonin 5-HT-1C receptor; serotonin 5-HT-2C receptor; serotonin receptor; serotonin receptor 2C; unnamed protein product
Gene Aliases: 5-HT-1C; 5-HT-2C; 5-HT1C; 5-HT2C; 5-HT2cR; 5-HTR2C; 5HT-1C; 5HT1c; 5HTR2C; HTR1C; SR1
UniProt ID: (Human) P28335, (Mouse) P34968, (Rat) P08909
Entrez Gene ID: (Human) 3358, (Mouse) 15560, (Rat) 25187
behavioral fear response
cellular calcium ion homeostasis
G-protein coupled receptor signaling pathway
G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger
phospholipase C-activating G-protein coupled receptor signaling pathway
phospholipase C-activating serotonin receptor signaling pathway
serotonin receptor signaling pathway
chemical synaptic transmission
locomotory behavior
feeding behavior
positive regulation of phosphatidylinositol biosynthetic process
regulation of neurological system process
regulation of appetite
regulation of corticotropin-releasing hormone secretion
release of sequestered calcium ion into cytosol
positive regulation of ERK1 and ERK2 cascade
G protein-coupled serotonin receptor signaling pathway
response to xenobiotic stimulus
positive regulation of gamma-aminobutyric acid secretion
positive regulation of acetylcholine secretion, neurotransmission
phospholipase D-activating G-protein coupled receptor signaling pathway
behavioral response to nicotine
positive regulation of fat cell differentiation
positive regulation of vasoconstriction
negative regulation of dopamine metabolic process
sensitization
positive regulation of calcium-mediated signaling
organ regeneration
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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