Fabgennix

5HT2C Receptor Polyclonal Antibody

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Datasheet
Protocols
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Datasheet
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5HT2C Receptor Polyclonal Antibody

Product Details

5HT2C-301AP

Applications
Tested Dilution
Publications

Western Blot (WB)

1:500-1:1,000
-

Immunohistochemistry (IHC)

1:50-1:250
-

ELISA (ELISA)

1:10,000
-

Immunoprecipitation (IP)

1:50-1:250
-
Product Specifications

Species Reactivity

Human, Mouse, Non-human primate, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Synthetic peptide taken within amino acid region 400-458 on human 5-hydroxytryptamine receptor 2C.
View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.5-1.5 mg/mL

Purification

Affinity chromatography

Storage buffer

proprietary buffer, pH 7.4-7.8, with 0.5% BSA, 30% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Ambient (domestic); Wet ice (international)

Target Information

Serotonin (5-hydroxytryptamine, 5-HT), a neurotransmitter, elicits a wide array of physiological effects by binding to several receptor subtypes, including the 5-HT2 family of seven-transmembrane-spanning, G-protein-coupled receptors, which activate phospholipase C and D signaling pathways. This gene encodes the 2C subtype of serotonin receptor and its mRNA is subject to multiple RNA editing events, where genomically encoded adenosine residues are converted to inosines. RNA editing is predicted to alter amino acids within the second intracellular loop of the 5-HT2C receptor and generate receptor isoforms that differ in their ability to interact with G proteins and the activation of phospholipase C and D signaling cascades, thus modulating serotonergic neurotransmission in the central nervous system. Studies in humans have reported abnormalities in patterns of 5-HT2C editing in depressed suicide victims.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: 5-HT-1C; 5-HT-2C; 5-HT1C; 5-HT1c receptor; 5-HT2C receptor; 5-hydroxytryptamine (serotonin) receptor 2C, G protein-coupled; 5-hydroxytryptamine receptor 1C; 5-hydroxytryptamine receptor 2C; 5HT2C Receptor; HGNC:5295; RP11-810O3.1; RP23-15B7.1; serotonin 1c receptor; serotonin 5-HT-1C receptor; serotonin 5-HT-2C receptor; Serotonin receptor 2C

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Gene Aliases: 5-HT1C; 5-HT2C; 5-HT2cR; 5-HTR2C; 5HT-1C; 5HT1c; 5HTR2C; HTR1C; HTR2C; SR1

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UniProt ID: (Human) P28335, (Rat) P08909, (Mouse) P34968

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Entrez Gene ID: (Human) 3358, (Rat) 25187, (Mouse) 15560

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Function(s)
Gq/11-coupled serotonin receptor activity G-protein coupled serotonin receptor activity drug binding serotonin binding 1-(4-iodo-2,5-dimethoxyphenyl)propan-2-amine binding protein binding signal transducer activity G-protein coupled receptor activity G-protein coupled receptor
Process(es)
behavioral fear response cGMP biosynthetic process cellular calcium ion homeostasis phospholipase C-activating G-protein coupled receptor signaling pathway phospholipase C-activating serotonin receptor signaling pathway serotonin receptor signaling pathway chemical synaptic transmission locomotory behavior feeding behavior positive regulation of phosphatidylinositol biosynthetic process regulation of neurological system process regulation of appetite response to drug regulation of corticotropin-releasing hormone secretion positive regulation of fat cell differentiation release of sequestered calcium ion into cytosol positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway positive regulation of ERK1 and ERK2 cascade G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger positive regulation of gamma-aminobutyric acid secretion positive regulation of acetylcholine secretion, neurotransmission organ regeneration phospholipase D-activating G-protein coupled receptor signaling pathway behavioral response to nicotine negative regulation of locomotion positive regulation of vasoconstriction negative regulation of dopamine metabolic process inositol phosphate-mediated signaling regulation of sensory perception of pain signal transduction G-protein coupled receptor signaling pathway behavior
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If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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