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Alomone Labs, LTD
5HT6 Receptor (HTR6) (extracellular) Polyclonal Antibody
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FIGURE: 1 / 3
5HT6 Receptor (HTR6) (extracellular) Antibody (ASR-038-200UL) in IHC (F)
Expression of 5HT6 in mouse hippocampus. Immunohistochemical staining of perfusion-fixed frozen mouse brain sections with Anti-5HT6 Receptor (HTR6) (extracellular) Antibody (#ASR-038) (1:300), followed by goat anti-rabbit-AlexaFluor-488. A. Staining in the hippocampal dentate gyrus region, showed 5HT6 immunoreactivity (green) in neuronal outlines in the hilus (H, left-pointing arrows) and in the granular la... View More
Product Details
ASR-038-200UL
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Peptide GPYKLSWVQENGTQDE, corresponding to amino acid residues 346-361 of mouse TYRO3. Extracellular, N-terminus.
Conjugate
Form
Lyophilized
Concentration
0.8 mg/mL
Amount
160 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.4, with 1% BSA
Contains
0.05% sodium azide
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
Product Specific Information
Immunogen sequence: GPYKLSWVQENGTQDE
Reconstitution: 25 uL, 50 uL or 0.2 mL double distilled water (DDW), depending on the sample size. The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20C. The reconstituted solution can be stored at 4C for up to 1 week. For longer periods, small aliquots should be stored at -20C. Avoid multiple freezing and thawing. Centrifuge all antibody preparations before use (10000 x g 5 min).
Target Information
This is one of the several different receptors for 5-hydroxytryptamine, a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. The activity of this receptor is mediated by G proteins that stimulate adenylate cyclase. It has a high affinity for tricyclic psychotropic drugs.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: 5-HT-6; 5-HT6; 5-HT6 receptor; 5-hydroxytryptamine receptor 6; Serotonin receptor 6; ST-B17
Gene Aliases: 5-HT6; Htr6
UniProt ID: (Mouse) Q9R1C8
Entrez Gene ID: (Mouse) 15565, (Rat) 64354
signal transduction
G-protein coupled receptor signaling pathway
G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger
serotonin receptor signaling pathway
learning
negative regulation of glutamate secretion
negative regulation of gamma-aminobutyric acid secretion
positive regulation of gamma-aminobutyric acid secretion
negative regulation of acetylcholine secretion, neurotransmission
cerebral cortex cell migration
positive regulation of TOR signaling
positive regulation of dopamine secretion
long-term synaptic potentiation
brain development
response to estradiol
response to drug
Disclaimer
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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