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Proteintech
CD38 Monoclonal Antibody (3C6G4)
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Product Details
60006-1-IG
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse
Host/Isotype
Mouse
/ IgG1
Class
Monoclonal
Type
Antibody
Clone
3C6G4
Immunogen
CD38 Fusion Protein Ag0487 (1-300 aa encoded by BC007964)
Conjugate
Form
Liquid
Concentration
0.88 mg/mL
Amount
132 µg
Purification
Protein A
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
Immunogen sequence: MANCEFSPV SGDKPCCRLS RRAQLCLGVS ILVLILVVVL AVVVPRWRQQ WSGPGTTKRF PETVLARCVK YTEIHPEMRH VDCQSVWDAF KGAFISKHPC NITEEDYQPL MKLGTQTVPC NKILLWSRIK DLAHQFTQVQ RDMFTLEDTL LGYLADDLTW CGEFNTSKIN YQSCPDWRKD CSNNPVSVFW KTVSRRFAEA ACDVVHVMLN GSRSKIFDKN STFGSVEVHN LQPEKVQTLE AWVIHGGRED SRDLCQDPTI KELESIISKR NIQFSCKNIY RPDKFLQCVK NPEDSSCTSE I (1-300 aa encoded by BC007964)
Target Information
CD38 is a multifunctional ectoenzyme and type II transmembrane glycoprotein involved in various cellular processes. It catalyzes the conversion of NAD into secondary messengers such as nicotinic acid adenine dinucleotide phosphate (NAADP) and cyclic ADP-ribose (cADPR). CD38 plays a crucial role in B cell development, with expression levels fluctuating from high in immature cells to low in intermediate ones, and back to high in mature B cells. It is also present in a variety of tissues and hematopoietic cells, including T cells, NK cells, and monocytes, and is used to phenotype leukemias and monitor HIV-1 progression. The CD34+CD38- population is considered to define the most pluripotent hematopoietic stem cells. In addition to its surface expression, CD38 has been identified in the nucleus, where it may regulate calcium levels. It functions as a multi-catalytic ectoenzyme, serving roles as an ADP-ribosyl cyclase, cyclic ADP-ribose hydrolase, and possibly NAD+ glycohydrolase, or as a cell surface receptor. CD38 is involved in the activation, proliferation, and differentiation of mature lymphocytes and mediates apoptosis of myeloid and lymphoid progenitor cells. It also participates in cell adhesion, signal transduction, and calcium signaling. Antibodies to CD38 are valuable for subtyping lymphomas and leukemias, detecting plasma cells (such as in myelomas), and marking activated B and T cells. CD38 is expressed at high levels in the pancreas, liver, kidney, malignant lymphoma, and neuroblastoma. Dysfunctions in CD38 are associated with diseases like chronic lymphocytic leukemia and Richter's Syndrome.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: 2'-phospho-ADP-ribosyl cyclase; 2'-phospho-ADP-ribosyl cyclase/2'-phospho-cyclic-ADP-ribose transferase; 2'-phospho-cyclic-ADP-ribose transferase; ADP-ribosyl cyclase 1; ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1; ADPRC 1; cADPR hydrolase 1; CD38; CD38 antigen (p45); CD38 antigen p45; cluster of differentiation 38; Cyclic ADP-ribose hydrolase 1; ecto-nicotinamide adenine dinucleotide glycohydrolase; I-19; lymphocyte differentiation antigen CD38; NAD(+) nucleosidase; NAD+ nucleosidase; NIM-R5 antigen; T10; unnamed protein product
Gene Aliases: ADPRC 1; ADPRC1; cADPR1; CD38; Cd38-rs1
UniProt ID: (Human) P28907, (Mouse) P56528
Entrez Gene ID: (Human) 952, (Mouse) 12494
response to hypoxia
signal transduction
positive regulation of cytosolic calcium ion concentration
female pregnancy
positive regulation of cell proliferation
response to xenobiotic stimulus
response to hormone
negative regulation of neuron projection development
artery smooth muscle contraction
NAD metabolic process
positive regulation of cell growth
positive regulation of B cell proliferation
positive regulation of insulin secretion
response to estradiol
response to retinoic acid
response to progesterone
response to hydroperoxide
response to cytokine
B cell proliferation
negative regulation of apoptotic process
negative regulation of bone resorption
negative regulation of transcription, DNA-templated
positive regulation of transcription, DNA-templated
positive regulation of vasoconstriction
B cell receptor signaling pathway
long term synaptic depression
response to interleukin-1
apoptotic signaling pathway
metabolic process
response to drug
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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