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Proteintech
GRP94 Monoclonal Antibody (4G7C7)
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Product Details
60012-2-IG
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Mouse
/ IgG1
Class
Monoclonal
Type
Antibody
Clone
4G7C7
Immunogen
GRP94 Fusion Protein Ag1439
Conjugate
Form
Liquid
Concentration
853 µg/mL
Amount
127.95 µg
Purification
Protein A
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice
Product Specific Information
Aliquoting is unnecessary for -20°C storage.
Target Information
GRP94 is a 803 amino acid protein belonging to the heat shock protein 90 family. It acts as a molecular chaperone that functions in the processing and transport of secreted proteins. GRP94 and its N-terminal fragment stimulates CTL expansion and maturation of human monocyte-derived dendritic cells (MDDC). It plays a central role in innate as well as acquired immunity, maturation and chemotaxis of dendritic cells, Ab production, cross-priming, as a potential marker in breast cancer and is a peptide acceptor in endoplasmic reticulum and an accessory to peptide loading of MHC class I molecules. Expression of GRP94 suppressed A23187-induced apoptosis and stabilized calcium homeostasis. GRP94 is expressed in melanoma or liver metastases of colon carcinoma cells, human gastric carcinoma BGC-823 cells.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: 94 kDa glucose-regulated protein; Endoplasmin; endothelial cell (HBMEC) glycoprotein; epididymis luminal protein 35; epididymis secretory sperm binding protein Li 125m; gp96 homolog; GRP-94; Heat shock protein 90 kDa beta member 1; heat shock protein 90kDa beta (Grp94), member 1; heat shock protein 90kDa beta family member 1; Heat shock protein family C member 4; stress-inducible tumor rejection antigen gp96; tumor rejection antigen (gp96) 1; Tumor rejection antigen 1; unnamed protein product
Gene Aliases: ECGP; GP96; GRP94; HEL-S-125m; HEL35; HSP90B1; HSPC4; TRA1
UniProt ID: (Human) P14625
Entrez Gene ID: (Human) 7184
nucleotide binding
RNA binding
protein phosphatase inhibitor activity
calcium ion binding
protein binding
ATP binding
hydrolase activity
ATPase activity
protein phosphatase binding
protein binding involved in protein folding
low-density lipoprotein particle receptor binding
unfolded protein binding
ATP-dependent protein folding chaperone
response to hypoxia
protein folding
protein transport
positive regulation of Wnt signaling pathway
retrograde protein transport, ER to cytosol
actin rod assembly
positive regulation of toll-like receptor signaling pathway
protein folding in endoplasmic reticulum
response to endoplasmic reticulum stress
ERAD pathway
negative regulation of apoptotic process
sequestering of calcium ion
cellular response to manganese ion
cellular response to ATP
protein localization to plasma membrane
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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