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Proteintech
Transgelin 2 Monoclonal Antibody (2E5G1)
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Product Details
60044-1-IG
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse
Host/Isotype
Mouse
/ IgG1
Class
Monoclonal
Type
Antibody
Clone
2E5G1
Immunogen
Transgelin 2 Fusion Protein Ag0337 (4-130 aa encoded by BC002616)
Conjugate
Form
Liquid
Concentration
1.2 mg/mL
Amount
180 µg
Purification
Caprylic acid precipitation
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.1% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
Our test results showed that this antibody Is specific to TAGLN2. It does not bind TAGLN1 and TAGLN3.
Immunogen sequence: RGPAYGLSR EVQQKIEKQY DADLEQILIQ WITTQCRKDV GRPQPGRENF QNWLKDGTVL CELINAQYPE GQAPVKKIQA STMAFKQMEQ ISQFLQAAER YGINTTDIFQ TVDLWEGKNM ACVQRTLM (4-130 aa encoded by BC002616)
Target Information
Transgelin (also designated SM22alpha), is expressed abundantly in smooth muscle cells. Transgelin-2 (also known as SM22alpha homolog) is a homolog of transgelin and is also expressed in smooth muscle cells and by peritoneal B-1 cells. The human transgelin-2 gene (designated TAGLN2), which is located on chromosome 1q231-q25, encodes a 199 amino acid protein that contains a calponin-like repeat and a calponin-homology (CH) domain. Transgelin-2 may function very similarly to transgelin. During embryogenesis, transgelin is expressed in smooth, cardiac and skeletal muscle, but is restricted during late fetal development and adulthood to all vascular and visceral smooth muscle cells and low levels of expression in heart. Transgelin is downregulated in several transformed cell lines, indicating that a reduction of transgelin expression may be an early indicator of the onset of transformation. Transgelin also binds actin, causing actin fibers to gel within minutes of binding. Binding of transgelin to actin occurs at a ratio of 1:6 actin monomers.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: epididymis secretory sperm binding protein; Epididymis tissue protein Li 7e; KIAA0120; similar to Homo sapiens mRNA for KIAA0120 gene with GenBank Accession Number D21261.1; SM22-alpha homolog; SM22-beta; TAGLN2; Transgelin-2; unnamed protein product
Gene Aliases: 2700094C18Rik; CDABP0035; HA1756; KIAA0120; Sm22a; Sm22B; SM22beta; TAGLN2
UniProt ID: (Human) P37802, (Mouse) Q9WVA4
Entrez Gene ID: (Human) 8407, (Mouse) 21346
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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