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Proteintech
IFITM1 Monoclonal Antibody (5B5E2)
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Product Details
60074-1-IG
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Published species
Human,
Mouse,
Virus
Host/Isotype
Mouse
/ IgG2a
Class
Monoclonal
Type
Antibody
Clone
5B5E2
Immunogen
IFITM1-Specific Fusion Protein Ag2320 (1-125 aa encoded by BC000897)
Conjugate
Form
Liquid
Concentration
1.5 mg/mL
Purification
Protein A
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.1% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
60074-1-Ig is a mouse monoclonal antibody which specifically recognizes IFITM1 but not IFITM2 or IFITM3.
Immunogen sequence: MHKEEHEVA VLGAPPSTIL PRSTVINIHS ETSVPDHVVW SLFNTLFLNW CCLGFIAFAY SVKSRDRKMV GDVTGAQAYA STAKCLNIWA LILGILMTIG FILLLVFGSV TVYHIMLQII QEKRGY (1-125 aa encoded by B C000897)
Target Information
IFITM1 (Interferon inducible transmembrane protein 1) is a member of the IFN-inducible transmembrane protein family. It is an essential mediator of interferon-gamma-induced antiproliferation and plays a role in the control of cell growth. IFITM1 is upregulated in several tumor types and may be useful as a tumor biomarker. Both mouse IFITM1 and IFITM3 are expressed on the cell surfaces of primordial germ cells in a developmentally-regulated manner. IFITM1 activity is required for primordial germ cell transit, and IFITM1 acts as a repulsive molecule by repelling non-IFITM1-expressing primordial germ cells from the mesoderm into the endoderm.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: 27-Sep; CD225; Dispanin subfamily A member 2a; DSPA2a; Interferon-induced protein 17; Interferon-induced transmembrane protein 1; Interferon-inducible protein 9-27; Leu-13 antigen; unnamed protein product
Gene Aliases: 9-27; CD225; DSPA2a; IFI17; IFITM1; LEU13
UniProt ID: (Human) P13164
Entrez Gene ID: (Human) 8519
ossification
immune system process
cell surface receptor signaling pathway
negative regulation of cell proliferation
response to virus
negative regulation of cell migration
response to interferon-gamma
response to interferon-alpha
response to interferon-beta
negative regulation of viral genome replication
innate immune response
positive regulation of osteoblast differentiation
negative regulation of viral entry into host cell
defense response to virus
type I interferon signaling pathway
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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