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Proteintech

TNFR1 Monoclonal Antibody (2A6E3)

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TNFR1 Monoclonal Antibody (2A6E3)

Product Details

60192-1-IG

Applications
Tested Dilution
Publications

Western Blot (WB)

1:2500-1:10,000
View 4 publications 4 publications

Immunohistochemistry (IHC)

-
View 1 publication 1 publication

Immunohistochemistry (Paraffin) (IHC (P))

1:50-1:500
-

Immunohistochemistry (PFA fixed) (IHC (PFA))

1:400
-

Immunocytochemistry (ICC/IF)

-
View 2 publications 2 publications

Flow Cytometry (Flow)

0.2 µg/1x10^6 cells
View 1 publication 1 publication

Miscellaneous PubMed (Misc)

-
View 1 publication 1 publication

Not applicable (N/A)

-
View 1 publication 1 publication
Product Specifications

Species Reactivity

Human, Mouse, Pig, Rat

Host/Isotype

Mouse / IgG1

Class

Monoclonal

Type

Antibody

Clone

2A6E3

Immunogen

TNFR1 Fusion Protein Ag16112 (235-455 aa encoded by BC010140)
View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1.44 mg/mL

Amount

216 µg

Purification

Protein G

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice (domestic); Dry ice (international)

Product Specific Information

Immunogen sequence: RYQRWKSKL YSIVCGKSTP EKEGELEGTT TKPLAPNPSF SPTPGFTPTL GFSPVPSSTF TSSSTYTPGD CPNFAAPRRE VAPPYQGADP ILATALASDP IPNPLQKWED SAHKPQSLDT DDPATLYAVV ENVPPLRWKE FVRRLGLSDH EIDRLELQNG RCLREAQYSM LATWRRRTPR REATLELLGR VLRDMDLLGC LEDIEEALCG PAALPPAPSL LR (235-455 aa encoded by BC010140)

Target Information

TNFR1 (Tumor necrosis factor receptor 1) belongs to the tumor necrosis factor superfamily, and is one of the major TNF-alpha receptors. TNFR1 plays an important role in mediating, in cytokine mediated signaling, positive regulation of the NF-Kb pathway, positive regulation of angiogenesis, and negative regulation of gene expression. The extracellular domain of TNFR1 is also released into the circulatory system as soluble TNFR1 (sTNFR1). In humans, the TNFR1 gene is located on chromosome 12. Anti-apoptotic protein BCL2-associated athanogene 4 (BAG4/SODD) and adaptor proteins TRADD and TRAF2 have been shown to interact with TNFR1, and thus play regulatory roles in the signal transduction mediated by the receptor. Germline mutations of the extracellular domains of TNFR1 were found to be associated with the autosomal dominant periodic fever syndrome, and the impaired receptor clearance is thought to be a mechanism of the disease.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Bioinformatics

Protein Aliases: CD120a; CD120a antigen; MGC19588; n-smase activation assoc. factor; p55; p55 TNF receptor; p60; p62; p63; sCD120a; soluble CD120a; soluble TNFR1; sTNF RI; sTNFR I; sTNFR1; sTNFRI; TNF alpha gene; TNF receptor alpha chain; TNF-alpha-R1; TNF-R1; TNF-RI; TNFR; TNFR I; TNFR-I; TNFR1 beta; tumor necrosis factor binding protein 1; Tumor necrosis factor receptor; Tumor necrosis factor receptor 1; Tumor necrosis factor receptor superfamily member 1A; tumor necrosis factor receptor type 1; Tumor necrosis factor receptor type I; tumor necrosis factor-alpha receptor; unnamed protein product

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Gene Aliases: CD120a; FPF; p55; p55-R; p60; TBP1; TNF-alphaR1; TNF-R; TNF-R-I; TNF-R1; TNF-R55; TNFalpha-R1; TNFAR; TNFR-1; Tnfr-2; TNFR1; TNFR55; TNFR60; TNFRI; TNFRp55; TNFRSF1A

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UniProt ID: (Pig) P50555, (Human) P19438, (Rat) P22934, (Mouse) P25118

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Entrez Gene ID: (Pig) 397020, (Human) 7132, (Rat) 25625, (Mouse) 21937

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Function(s)
tumor necrosis factor-activated receptor activity protein binding signaling receptor activity tumor necrosis factor binding protease binding protein complex binding transmembrane signal receptor
Process(es)
prostaglandin metabolic process apoptotic process defense response inflammatory response cell surface receptor signaling pathway cytokine-mediated signaling pathway tumor necrosis factor-mediated signaling pathway positive regulation of transcription from RNA polymerase II promoter positive regulation of inflammatory response aortic valve development pulmonary valve development negative regulation of extracellular matrix constituent secretion transcription from RNA polymerase II promoter signal transduction JAK-STAT cascade extrinsic apoptotic signaling pathway via death domain receptors intrinsic apoptotic signaling pathway in response to DNA damage regulation of gene expression positive regulation of macromolecule biosynthetic process negative regulation of cardiac muscle hypertrophy regulation of tumor necrosis factor-mediated signaling pathway positive regulation of cellular amide metabolic process NIK/NF-kappaB signaling defense response to bacterium positive regulation of I-kappaB kinase/NF-kappaB signaling positive regulation of lipid metabolic process negative regulation of inflammatory response regulation of developmental process regulation of multicellular organismal process cellular response to mechanical stimulus protein localization to plasma membrane apoptotic signaling pathway positive regulation of execution phase of apoptosis positive regulation of apoptotic process involved in morphogenesis regulation of establishment of endothelial barrier regulation of membrane lipid metabolic process response to hypoxia response to wounding positive regulation of gene expression negative regulation of gene expression programmed cell death response to lipopolysaccharide negative regulation of interleukin-6 production positive regulation of tumor necrosis factor production tetrapyrrole metabolic process positive regulation of protein import into nucleus, translocation positive regulation of tyrosine phosphorylation of Stat1 protein regulation of apoptotic process negative regulation of apoptotic process response to amino acid response to alkaloid positive regulation of neuron apoptotic process response to ethanol positive regulation of angiogenesis protein heterooligomerization cellular response to estradiol stimulus
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