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Proteintech
CD7 Monoclonal Antibody (1G10D8)
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Product Details
60209-1-IG
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse
Host/Isotype
Mouse
/ IgG1
Class
Monoclonal
Type
Antibody
Clone
1G10D8
Immunogen
CD7 Fusion Protein Ag1805 (1-240 aa encoded by BC009293)
Conjugate
Form
Liquid
Concentration
1.1 mg/mL
Purification
Protein G
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
Immunogen sequence: MAGPPRLLL LPLLLALARG LPGALAAQEV QQSPHCTTVP VGASVNITCS TSGGLRGIYL RQLGPQPQDI IYYEDGVVPT TDRRFRGRID FSGSQDNLTI TMHRLQLSDT GTYTCQAITE VNVYGSGTLV LVTEEQSQGW HRCSDAPPRA SALPAPPTGS ALPDPQTASA LPDPPAASAL PAALAVISFL LGLGLGVACV LARTQIKKLC SWRDKNSAAC VVYEDMSHSR CNTLSSPNQY Q (1-240 aa encoded by BC009293)
Target Information
CD7, also known as gp40 or Leu9, is a 40 kDa receptor and member of the immunoglobulin gene superfamily. It features an N-terminal region (amino acids 1-107) that is highly homologous to Ig kappa light chains, while its carboxyl-terminal region is proline-rich, forming a stalk from which the Ig domain projects. CD7 is prominently expressed on the majority of immature and mature T lymphocytes, as well as T cell leukemias. It is also found on natural killer cells, a small subpopulation of normal B cells, and malignant B cells. CD7 plays a crucial role in modulating immune cell activity. Cross-linking of surface CD7 enhances T cell and NK cell functions, as evidenced by increased calcium flux, expression of adhesion molecules, cytokine secretion, and proliferation. CD7 directly associates with phosphoinositol 3-kinase, and its ligation induces the production of D-3 phosphoinositides and tyrosine phosphorylation. The expression of CD7 is an important marker in leukemia diagnostics, highlighting its significance in both normal immune function and disease states.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: CD7; CD7 antigen (p41); GP40; p41 protein; T-cell antigen CD7; T-cell leukemia antigen; T-cell surface antigen Leu-9; TP41; unnamed protein product
Gene Aliases: CD7; GP40; LEU-9; Tp40; TP41
UniProt ID: (Human) P09564, (Mouse) P50283
Entrez Gene ID: (Human) 924, (Mouse) 12516
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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