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          • Primary Antibodies ›
          • Lyn Antibodies

          Proteintech

          LYN Monoclonal Antibody (3C7F2)

          2 References
          View all (42) Lyn antibodies

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          Cite LYN Monoclonal Antibody (3C7F2)

          Additional Information:
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          • Antibody Testing Data (5)
          LYN Antibody in Immunohistochemistry (Paraffin) (IHC (P))
          Group 53 Created with Sketch.
          LYN Antibody in Immunohistochemistry (Paraffin) (IHC (P))
          Group 53 Created with Sketch.

          FIGURE: 1 / 5

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          LYN Antibody (60211-1-IG) in IHC (P)

          Immunohistochemistry of paraffin-embedded human placenta tissue slide using 60211-1-IG ( LYN Antibody) at dilution of 1:50 (under 40x lens). {{ $ctrl.currentElement.advancedVerification.fullName }} validation info. View more
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          View Product

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          LYN Antibody in Immunohistochemistry (Paraffin) (IHC (P))
          LYN Antibody in Immunohistochemistry (Paraffin) (IHC (P))
          LYN Antibody in Western Blot (WB)
          LYN Antibody in Western Blot (WB)
          LYN Antibody in Western Blot (WB)
          LYN Monoclonal Antibody (3C7F2)

          Product Details

          60211-1-IG

          Applications
          Tested Dilution
          Publications

          Western Blot (WB)

          1:500-1:2,000
          View 2 publications 2 publications

          Immunohistochemistry (Paraffin) (IHC (P))

          1:20-1:200
          -
          Product Specifications

          Species Reactivity

          Human, Mouse

          Host/Isotype

          Mouse / IgG2a

          Class

          Monoclonal

          Type

          Antibody

          Clone

          3C7F2

          Immunogen

          LYN Fusion Protein Ag12723 (132-512 aa encoded by BC075002)
          3D Epitope / Immunogen

          Conjugate

          Unconjugated Unconjugated Unconjugated
          • CoraLite Plus 488
          • Request custom conjugation

          Form

          Liquid

          Concentration

          1.08 mg/mL

          Amount

          162 µg

          Purification

          Protein A

          Storage buffer

          PBS, pH 7.3, with 50% glycerol

          Contains

          0.02% sodium azide

          Storage conditions

          -20°C

          Shipping conditions

          Wet ice (domestic); Dry ice (international)

          Product Specific Information

          Immunogen sequence: KDITRKDAE RQLLAPGNSA GAFLIRESET LKGSFSLSVR DFDPVHGDVI KHYKIRSLDN GGYYISPRIT FPCISDMIKH YQKQADGLCR RLEKACISPK PQKPWDKDAW EIPRESIKLV KRLGAGQFGE VWMGYYNNST KVAVKTLKPG TMSVQAFLEE ANLMKTLQHD KLVRLYAVVT REEPIYIITE YMAKGSLLDF LKSDEGGKVL LPKLIDFSAQ IAEGMAYIER KNYIHRDLRA ANVLVSESLM CKIADFGLAR VIEDNEYTAR EGAKFPIKWT APEAINFGCF TIKSDVWSFG ILLYEIVTYG KIPYPGRTNA DVMTALSQGY RMPRVENCPD ELYDIMKMCW KEKAEERPTF DYLQSVLDDF YTATEGQYQQ QP (132-512 aa encoded by BC075002)

          Target Information

          Lyn proto oncogene (Lcl/Yes related novel protein tyrosine kinase) is encoded by the Lyn gene located on chromosome 8 in humans and belongs to the Src family kinase. It is a non-receptor tyrosine kinase that acts as a mediator in transducing cellular signaling. The most well studied expression of Lyn is in hematopoietic cell types, both lymphoid and myeloid cells with exclusion in T lymphocytes. It has also been observed that Lyn plays diverse roles such as in regulation of B cell receptor signaling, mast cell signaling and Epithelial - Mesenchymal Transition (EMT).

          For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

          Bioinformatics

          Protein Aliases: FLJ26625; Lck/Yes-related novel protein tyrosine kinase; lyn tyrosine kinase; p53Lyn; p56Lyn; Tyrosine-protein kinase Lyn; unnamed protein product; V-yes-1 Yamaguchi sarcoma viral related oncogene homolog

          View more View less

          Gene Aliases: AA407514; Hck-2; JTK8; LYN; p53Lyn; p56Lyn; SAIDV

          View more View less

          UniProt ID: (Human) P07948, (Mouse) P25911

          View more View less

          Entrez Gene ID: (Human) 4067, (Mouse) 17096

          View more View less

          Function(s)
          nucleotide binding protein kinase activity protein tyrosine kinase activity non-membrane spanning protein tyrosine kinase activity receptor binding platelet-derived growth factor receptor binding integrin binding protein binding ATP binding kinase activity transferase activity SH3 domain binding enzyme binding receptor activator activity ubiquitin protein ligase binding gamma-tubulin binding glycosphingolipid binding ion channel binding macromolecular complex binding ephrin receptor binding phosphoprotein binding scaffold protein binding phosphorylation-dependent protein binding phosphatidylinositol 3-kinase activator activity erythropoietin receptor binding transferase activity, transferring phosphorus-containing groups protein complex binding
          Process(es)
          B cell homeostasis regulation of cytokine production negative regulation of protein phosphorylation immune system process Fc receptor mediated stimulatory signaling pathway tolerance induction to self antigen histamine secretion by mast cell platelet degranulation negative regulation of myeloid leukocyte differentiation immune response-regulating cell surface receptor signaling pathway Fc receptor mediated inhibitory signaling pathway regulation of B cell apoptotic process protein phosphorylation inflammatory response cellular response to DNA damage stimulus signal transduction transmembrane receptor protein tyrosine kinase signaling pathway positive regulation of cell proliferation negative regulation of cell proliferation response to hormone positive regulation of neuron projection development phosphorylation peptidyl-tyrosine phosphorylation hemopoiesis erythrocyte differentiation positive regulation of cell migration negative regulation of B cell proliferation neuron projection development lipopolysaccharide-mediated signaling pathway regulation of mast cell activation regulation of cell adhesion mediated by integrin negative regulation of toll-like receptor 2 signaling pathway negative regulation of toll-like receptor 4 signaling pathway intracellular signal transduction peptidyl-tyrosine autophosphorylation positive regulation of phosphorylation positive regulation of tyrosine phosphorylation of STAT protein hemoglobin biosynthetic process regulation of mast cell degranulation negative regulation of MAP kinase activity positive regulation of phosphatidylinositol 3-kinase activity innate immune response regulation of erythrocyte differentiation protein autophosphorylation cytokine secretion regulation of cytokine secretion regulation of inflammatory response positive regulation of peptidyl-tyrosine phosphorylation B cell receptor signaling pathway regulation of B cell receptor signaling pathway positive regulation of B cell receptor signaling pathway positive regulation of cellular component movement regulation of release of sequestered calcium ion into cytosol positive regulation of glial cell proliferation positive regulation of Fc receptor mediated stimulatory signaling pathway positive regulation of stress-activated protein kinase signaling cascade regulation of ERK1 and ERK2 cascade negative regulation of ERK1 and ERK2 cascade positive regulation of oligodendrocyte progenitor proliferation negative regulation of mast cell proliferation positive regulation of mast cell proliferation cellular response to retinoic acid cellular response to peptide hormone stimulus regulation of monocyte chemotaxis regulation of platelet aggregation dendritic cell differentiation negative regulation of intracellular signal transduction positive regulation of dendritic cell apoptotic process DNA damage checkpoint cell morphogenesis regulation of protein phosphorylation stimulatory C-type lectin receptor signaling pathway hematopoietic progenitor cell differentiation adaptive immune response innate immune response-activating signal transduction negative regulation of inflammatory response to antigenic stimulus autophagy response to stress response to sterol depletion response to xenobiotic stimulus response to toxic substance response to carbohydrate oligodendrocyte development fatty acid transport eosinophil differentiation T cell costimulation response to insulin toll-like receptor 4 signaling pathway cellular response to heat interleukin-5-mediated signaling pathway Fc-epsilon receptor signaling pathway Fc-gamma receptor signaling pathway involved in phagocytosis C-X-C chemokine receptor CXCR4 signaling pathway B cell proliferation response to amino acid positive regulation of MAPK cascade response to peptide hormone ephrin receptor signaling pathway response to axon injury negative regulation of immune response negative regulation of B cell receptor signaling pathway leukocyte migration JAK-STAT cascade involved in growth hormone signaling pathway cellular response to lipid neuroinflammatory response positive regulation of amyloid precursor protein catabolic process positive regulation of protein localization to plasma membrane
          It has to be done as per old AB suggested Products section.

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