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Proteintech
PRDX4 Monoclonal Antibody (5B6F1)
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Product Details
60286-1-IG
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Mouse
/ IgG2b
Class
Monoclonal
Type
Antibody
Clone
5B6F1
Immunogen
PRDX4 Fusion Protein Ag13401 (1-271 aa encoded by BC007107)
Conjugate
Form
Liquid
Concentration
0.73 mg/mL
Amount
109.5 µg
Purification
Protein A
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
Immunogen sequence: MEALPLLAA TTPDHGRHRR LLLLPLLLFL LPAGAVQGWE TEERPRTREE ECHFYAGGQV YPGEASRVSV ADHSLHLSKA KISKPAPYWE GTAVIDGEFK ELKLTDYRGK YLVFFFYPLD FTFVCPTEII AFGDRLEEFR SINTEVVACS VDSQFTHLAW INTPRRQGGL GPIRIPLLSD LTHQISKDYG VYLEDSGHTL RGLFIIDDKG ILRQITLNDL PVGRSVDETL RLVQAFQYTD KHGEVCPAGW KPGSETIIPD PAGKLKYFDK LN (1-271 aa encoded by BC007107)
Target Information
Peroxiredoxin (Prx) is a growing peroxidase family, whose mammalian members have been known to connect with cell proliferation, differentiation, and apoptosis. Many isoforms (about 50 proteins), collected in accordance to the amino acid sequence homology, containing active site cysteine residue, and the thiol-specific antioxidant activity, distribute throughout all the kingdoms. Among them, mammalian Prx consists of 6 different members grouped into typical 2-Cys, atypical 2-Cys Prx, and 1-Cys Prx. Except Prx VI belonging to 1-Cys Prx subgroup, the other five 2-Cys Prx isotypes have the thioredoxin-dependent peroxidase (TPx) activity utilizing thioredoxin, thioredoxin reductase, and NADPH as a reducing system. Mammalian Prxs are 20-30 kilodalton in molecular size and vary in subcellular localization: Prx I, II, and VI in cytosol, Prx III in mitochondria, Prx IV in ER and secretion, Prx V showing complicated distribution including peroxisome, mitochondria and cytosol.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: Antioxidant enzyme AOE372; AOE37-2; EC 1.11.1.15; epididymis secretory sperm binding protein Li 97n; Peroxiredoxin IV; Peroxiredoxin-4; PRDX4; Prx 4; Prx IV; Prx-IV; Thioredoxin dependent peroxide reductase A0372; thioredoxin peroxidase (antioxidant enzyme); Thioredoxin peroxidase AO372; Thioredoxin-dependent peroxide reductase A0372; Thioredoxin-dependent peroxiredoxin 4
Gene Aliases: AOE37-2; AOE372; HEL-S-97n; PRDX4; PRX-4; Prx-iv; Prx4; Rno2CysPrx04; TRANK
UniProt ID: (Human) Q13162, (Rat) Q9Z0V5, (Mouse) O08807
Entrez Gene ID: (Human) 10549, (Rat) 85274, (Mouse) 53381
peroxidase activity
protein binding
thioredoxin peroxidase activity
antioxidant activity
oxidoreductase activity
identical protein binding
peroxiredoxin activity
binding, bridging
molecular sequestering activity
thioredoxin-dependent peroxiredoxin activity
protein homodimerization activity
peroxidase
response to oxidative stress
I-kappaB phosphorylation
spermatogenesis
male gonad development
extracellular matrix organization
hydrogen peroxide catabolic process
cell redox homeostasis
protein maturation
reactive oxygen species metabolic process
cellular oxidant detoxification
negative regulation of male germ cell proliferation
4-hydroxyproline metabolic process
protein maturation by protein folding
oxidation-reduction process
Disclaimer
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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