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Proteintech
PLAP Monoclonal Antibody (2B7C9)
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Product Details
60294-1-IG
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Mouse
/ IgG1
Class
Monoclonal
Type
Antibody
Clone
2B7C9
Immunogen
PLAP Fusion Protein Ag13361 (199-535 aa encoded by BC009647)
Conjugate
Form
Liquid
Concentration
0.6 mg/mL
Amount
90 µg
Purification
Protein G
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
Immunogen sequence: SARQEGCQD IATQLISNMD IDVILGGGRK YMFRMGTPDP EYPDDYSQGG TRLDGKNLVQ EWLAKRQGAR YVWNRTELMQ ASLDPSVTHL MGLFEPGDMK YEIHRDSTLD PSLMEMTEAA LRLLSRNPRG FFLFVEGGRI DHGHHESRAY RALTETIMFD DAIERAGQLT SEEDTLSLVT ADHSHVFSFG GYPLRGSSIF GLAPGKARDR KAYTVLLYGN GPGYVLKDGA RPDVTESESG SPEYRQQSAV PLDEETHAGE DVAVFARGPQ AHLVHGVQEQ TFIAHVMAFA ACLEPYTACD LAPPAGTTDA AHPGRSVVPA LLPLLAGTLL LLETATAP (199-535 aa encoded by BC009647)
Target Information
Placental Alkaline Phosphatase plays an important role in the regulation of specific inflammatory disease processes. There are at least four distinct but related alkaline phosphatases: intestinal, placental, placental-like, and liver/bone/kidney for this form of alkaline phosphatase have been well characterized. Placental Alkaline Phosphatase reacts with a membrane-bound isoenzyme (Regan and Nagao type) of Placental Alkaline Phosphatase (PLAP) occurring in the placenta during the 3rd trimester of gestation. Placental Alkaline Phosphatase is useful in the identification of testicular germ cell tumors. Unlike germ cell tumors, PLAP-positive somatic cell tumors uniformly express epithelial membrane antigen (EMA). A proposed function of Placental Alkaline Phosphatase is matrix mineralization; however, mice that lack a functional form of this enzyme show normal skeletal development. Placental Alkaline Phosphatase has been linked directly to hypophosphatasia, a disorder that is characterized by hypercalcemia and includes skeletal defects. The character of hypophosphatasia can vary, however, depending on the specific mutation since this determines age of onset and severity of symptoms.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: Alkaline phosphatase placental type; Alkaline phosphatase Regan isozyme; Alkaline phosphatase, placental type; alkaline phosphomonoesterase; Alp1; AP-TNAP; DOA1; FLJ11281; FLJ40094; FLJ61142; FLJ93059; Germ-cell alkaline phosphatase; glycerophosphatase; HOPS; Intestinal alkaline phosphatase; Intestinal-type alkaline phosphatase; MGC161443; MGC167935; nagao Isozyme; P PLAP; PLA2P; PLAA; Placental alkaline phosphatase 1; placental alkaline phosphatase precursor; placental heat-stable alkaline phosphatase; PLAP-1; PLAP1; preplacental alkaline phosphatase (EC 3.1.3.1); preplacental alkaline phosphatase type 1 (EC 3.1.3.1); Regan isozyme; TNAP; TNSALP; unnamed protein product
Gene Aliases: ALP; ALPI; ALPP; IAP; PALP; PLAP; PLAP-1
UniProt ID: (Human) P05187
Entrez Gene ID: (Human) 250
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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