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Cytokeratin 5/8 Antibody Cocktail
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Product Details
61031
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Bovine,
Human,
Mouse
Host/Isotype
Mouse
/ IgG1
Class
Cocktail
Type
Antibody
Clone
Ks 5+8.22/C 22
Immunogen
Human Keratin K8, Purified From Sds Page Gel
Conjugate
Form
Lyophilized
Concentration
0.05 mg/mL
Amount
50 µg
Purification
Affinity chromatography
Storage buffer
PBS, pH 7.4, with 0.5% BSA
Contains
0.09% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
Product Specific Information
Reconstitute lyophilized product with 1 mL distilled water.
61031 is a mixture of monoclonal antibodies that target Cytokeratin 5/8.
C 22 represents an excellent marker for distinguishing carcinomas from all non-epithelial tumors. The antibody specifically reacts with keratins K5 and K8 present in nearly all epithelia. Polypeptide reacting: MW 52 500, MW 58 000 keratins (type II keratins K5 and K8; formerly also designated cytokeratins 5 and 8) of human epithelial cells.
Target Information
Cytokeratins are a subfamily of intermediate filament proteins and are characterized by a remarkable biochemical diversity, represented in human epithelial tissues by at least 20 different polypeptides. They range in molecular weight between ~40 kDa and ~68 kDa and isoelectric pH between 4.9 - 7.8. The individual human cytokeratins are numbered 1 to 20. The various epithelia in the human body usually express cytokeratins which are not only characteristic of the type of epithelium, but also related to the degree of maturation or differentiation within an epithelium. Cytokeratin subtype expression patterns are used to an increasing extent in the distinction of different types of epithelial malignancies. The cytokeratin antibodies are not only of assistance in the differential diagnosis of tumors using immunohistochemistry on tissue sections, but are also a useful tool in cytopathology and flow cytometric assays.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: 58 kDa cytokeratin; CK-5; CK-8; cytokeratin 5; cytokeratin 8; Cytokeratin endo A; cytokeratin type II, component III; Cytokeratin-5; Cytokeratin-8; Cytokeratin-A; epidermolysis bullosa simplex 2 Dowling-Meara/Kobner/Weber-Cockayne types; K5; K8; KERA; keratin 5 (epidermolysis bullosa simplex, Dowling-Meara/Kobner/Weber-Cockayne types); keratin 5, type II; keratin 8, type II; keratin complex 2, basic, gene 5; keratin complex 2, basic, gene 8; keratin K5; keratin type II; Keratin, type II cytoskeletal 5; keratin, type II cytoskeletal 60 kDa, component III; Keratin, type II cytoskeletal 8; Keratin-5; Keratin-8; KRT5; tuftelin interacting protein 8; type II cytokeratin A (no.8); Type-II keratin Kb5; Type-II keratin Kb8; unnamed protein product
Gene Aliases: 3300001P10Rik; AA960620; AL022697; AU019895; AW146334; CARD2; CK-8; CK5; CK8; CYK8; DDD; DDD1; EBS1; EBS2; EBS2A; EBS2B; EBS2C; EBS2D; EBS2E; EBS2F; EndoA; K2C8; K5; K8; KO; Krt-2.8; Krt2-5; KRT2-8; KRT5; KRT5A; KRT8; Tfip8
UniProt ID: (Bovine) Q5XQN5, (Human) P13647, (Bovine) P05786, (Human) P05787, (Mouse) Q922U2, (Mouse) P11679
Entrez Gene ID: (Bovine) 281268, (Human) 3852, (Bovine) 281269, (Human) 3856, (Mouse) 110308, (Mouse) 16691
epithelial cell differentiation
negative regulation of epithelial cell proliferation
tumor necrosis factor-mediated signaling pathway
response to other organism
cell differentiation involved in embryonic placenta development
extrinsic apoptotic signaling pathway
hepatocyte apoptotic process
cell morphogenesis involved in differentiation
multicellular organism development
sarcomere organization
response to hydrostatic pressure
epidermis development
response to mechanical stimulus
regulation of cell migration
keratinization
regulation of protein localization
intermediate filament polymerization
intermediate filament organization
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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