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Active Motif
Tet1 Monoclonal Antibody (5D6)
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FIGURE: 1 / 1
Tet1 Antibody (61742) in ChIP-Seq
TET1 antibody tested by ChIP-Seq. ChIP was performed using TET1 antibody with 30 µg chromatin from human brain tumor cells and 4 µl of antibody. ChIP DNA was sequenced on the Illumina HiSeq and 15 million sequence tags were mapped to identify TET1 binding sites. The image shows binding across a region of chromosome 1.
Product Details
61742
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse
Published species
Mouse
Host/Isotype
Rat
/ IgG2a
Class
Monoclonal
Type
Antibody
Clone
5D6
Immunogen
This antibody was raised against a recombinant protein corresponding amino acids 1682-1914 of mouse Tet1.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Amount
10 µg
Purification
Protein G
Storage buffer
PBS, pH 7.5, with 30% glycerol
Contains
0.035% sodium azide
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
Target Information
Dioxygenase that specifically binds methylcytosine (5mC), a minor base in mammalian DNA found in repetitive DNA elements that is crucial for retrotransposon silencing and mammalian development. Catalyzes the conversion of methylcytosine (5mC) to 5-hydroxymethylcytosine (hmC). The clear function of 5-hydroxymethylcytosine (hmC) is still unclear but it may influence chromatin structure and recruit specific factors or may constitute an intermediate component in cytosine demethylation. 5-hydroxymethylcytosine (hmC) is present in ES cells and is enriched in the brain, especially in Purkinje neurons. May play a role in the fetal development of heart, lung and brain.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: CXXC finger 6; CXXC zinc finger 6; CXXC-type zinc finger protein 6; LCX; Leukemia-associated protein with a CXXC domain; Methylcytosine dioxygenase TET1; RP11-119F7.1; Ten-eleven translocation 1 gene protein; Ten-eleven translocation 1 gene protein homolog; ten-eleven translocation-1; tet oncogene 1
Gene Aliases: 2510010B09Rik; AA517754; bA119F7.1; BB001228; CXXC6; D10Ertd17e; KIAA1676; LCX; mKIAA1676; TET1
UniProt ID: (Human) Q8NFU7, (Mouse) Q3URK3
Entrez Gene ID: (Human) 80312, (Mouse) 52463
RNA polymerase II core promoter proximal region sequence-specific DNA binding
DNA binding
iron ion binding
protein binding
zinc ion binding
methyl-CpG binding
oxidoreductase activity
oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors
metal ion binding
dioxygenase activity
methylcytosine dioxygenase activity
structure-specific DNA binding
negative regulation of transcription from RNA polymerase II promoter
inner cell mass cell differentiation
chromatin organization
chromatin remodeling
protein O-linked glycosylation
regulation of gene expression
positive regulation of macromolecule biosynthetic process
stem cell population maintenance
negative regulation of cell migration
negative regulation of transforming growth factor beta receptor signaling pathway
cellular response to reactive oxygen species
regulation of gene expression, epigenetic
hypomethylation of CpG island
positive regulation of transcription from RNA polymerase II promoter
negative regulation of stem cell population maintenance
positive regulation of stem cell population maintenance
transcription, DNA-templated
regulation of transcription, DNA-templated
chromatin modification
regulation of DNA methylation
oxidation-reduction process
DNA demethylation
negative regulation of methylation-dependent chromatin silencing
regulation of genetic imprinting
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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