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Proteintech
CD33 Monoclonal Antibody (WM53)
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Product Details
65272-1-IG
Product Specifications
Species Reactivity
Human
Host/Isotype
Mouse
/ IgG1, kappa
Class
Monoclonal
Type
Antibody
Clone
WM53
Immunogen
The exact sequence is proprietary
Conjugate
Form
Liquid
Amount
100 µg
Purification
Affinity chromatography
Storage buffer
PBS
Contains
0.09% sodium azide
Storage conditions
4°C
Shipping conditions
Wet ice
Target Information
CD33 is a transmembrane protein of the sialic acid-binding immunoglobulin-like lectin (Siglec) family. It belongs to the immunoreceptor tyrosine-based inhibitory motif (ITIM)-containing molecules able of recruiting protein tyrosine phosphatases SHP-1 and SHP-2 to signal assemblies, and these ITIMs are also used for ubiquitin-mediated removal of the receptor from the cell surface. CD33 is expressed on cells of myelomonocytic lineage, binds sialic acid residues in N- and O-glycans on cell surfaces, and is a therapeutic target for acute myeloid leukemia. Further, CD33 is found on granulocyte and macrophage precursors in the bone marrow, but is not on pluripotent stem cells. CD33 is also expressed on, and is a useful marker for, peripheral monocytes. CD33 is useful for distinguishing myelogenous leukemia cells from lymphoid or erythroid leukemias. Diseases associated with CD43 dysfunction include gallbladder lymphoma and extracutaneous mastocytoma.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: CD33; CD33 antigen (gp67); CD33 molecule transcript; FLJ00391; gp67; lacks exon 2 but includes exon 7a; Myeloid cell surface antigen CD33; Sialic acid-binding Ig-like lectin 3; Siglec-3; unnamed protein product
Gene Aliases: CD33; CD33rSiglec; p67; SIGLEC-3; SIGLEC3
UniProt ID: (Human) P20138
Entrez Gene ID: (Human) 945
immune response-inhibiting signal transduction
cell adhesion
signal transduction
cell-cell signaling
negative regulation of cell proliferation
negative regulation of interleukin-1 beta production
negative regulation of interleukin-8 production
negative regulation of tumor necrosis factor production
Fc-gamma receptor signaling pathway
positive regulation of protein secretion
cell-cell adhesion
negative regulation of monocyte activation
Disclaimer
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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